Peng Xie1, Jian-Min Huang1, Ying Li2, Huai-Jun Liu3, Yan Qu4. 1. Institute of Nuclear Medicine, The Third Hospital, Hebei Medical University, No.139 Ziqiang Road, Qiaoxi District, Shijiazhuang, Hebei, 050051, People's Republic of China. 2. Institute of Nephrology, The Third Hospital, Hebei Medical University, No.139 Ziqiang Road, Qiaoxi District, Shijiazhuang, Hebei, 050051, People's Republic of China. 3. Institute of Radiology, the Second Hospital, Hebei Medical University, No.215 Heping Road, Xinhua District, Shijiazhuang, Hebei, 050005, People's Republic of China. woxinfly1982@126.com. 4. Department of Research, The Third Hospital, Hebei Medical University, No.139 Ziqiang Road, Qiaoxi District, Shijiazhuang, Hebei, 050051, People's Republic of China.
Abstract
AIM: To investigate the application of the new modified Chronic Kidney Disease Epidemiology Collaboration (mCKD-EPI) equation developed by Liu for the measurement of glomerular filtration rate (GFR) in Chinese patients with chronic kidney disease (CKD) and to evaluate whether this modified form is more accurate than the original one in clinical practice. METHODS: GFR was determined simultaneously by 3 methods: (a) 99mTc-diethylene triamine pentaacetic acid (99mTc-DTPA) dual plasma sample clearance method (mGFR), which was used as the reference standard; (b) CKD-EPI equation (eGFRckdepi); (c) modified CKD-EPI equation (eGFRmodified). Concordance correlation and Passing-Bablok regression were used to compare the validity of eGFRckdepi and eGFRmodified. Bias, precision and accuracy were compared to identify which equation showed the better performance in determining GFR. RESULTS: A total of 170 patients were enrolled. Both eGFRckdepi and eGFRmodified correlated well with mGFR (concordance correlation coefficient 0.90 and 0.74, respectively) and the Passing-Bablok regression equation of eGFRckdepi and eGFRmodified against mGFR was mGFR = 0.37 + 1.04 eGFRckdepi and -49.25 + 1.74 eGFRmodified, respectively. In terms of bias, precision and 30 % accuracy, eGFRmodified showed a worse performance compared to eGFRckdepi, in the whole cohort. CONCLUSIONS: The new modified CKD-EPI equation cannot replace the original CKD-EPI equation in determining GFR in Chinese patients with CKD.
AIM: To investigate the application of the new modified Chronic Kidney Disease Epidemiology Collaboration (mCKD-EPI) equation developed by Liu for the measurement of glomerular filtration rate (GFR) in Chinese patients with chronic kidney disease (CKD) and to evaluate whether this modified form is more accurate than the original one in clinical practice. METHODS: GFR was determined simultaneously by 3 methods: (a) 99mTc-diethylene triamine pentaacetic acid (99mTc-DTPA) dual plasma sample clearance method (mGFR), which was used as the reference standard; (b) CKD-EPI equation (eGFRckdepi); (c) modified CKD-EPI equation (eGFRmodified). Concordance correlation and Passing-Bablok regression were used to compare the validity of eGFRckdepi and eGFRmodified. Bias, precision and accuracy were compared to identify which equation showed the better performance in determining GFR. RESULTS: A total of 170 patients were enrolled. Both eGFRckdepi and eGFRmodified correlated well with mGFR (concordance correlation coefficient 0.90 and 0.74, respectively) and the Passing-Bablok regression equation of eGFRckdepi and eGFRmodified against mGFR was mGFR = 0.37 + 1.04 eGFRckdepi and -49.25 + 1.74 eGFRmodified, respectively. In terms of bias, precision and 30 % accuracy, eGFRmodified showed a worse performance compared to eGFRckdepi, in the whole cohort. CONCLUSIONS: The new modified CKD-EPI equation cannot replace the original CKD-EPI equation in determining GFR in Chinese patients with CKD.
Authors: M D Blaufox; M Aurell; B Bubeck; E Fommei; A Piepsz; C Russell; A Taylor; H S Thomsen; D Volterrani Journal: J Nucl Med Date: 1996-11 Impact factor: 10.057