Kiyoshi Makiyama1, Ryoji Hirai2, Hiroumi Matsuzaki2. 1. Department of Otorhinolaryngology, Nihon University Hospital, 1-6 Kandasurugadai, Chiyoda, Tokyo 101-8309, Japan.. Electronic address: mak@med.email.ne.jp. 2. Department of Otorhinolaryngology, Nihon University Hospital, 1-6 Kandasurugadai, Chiyoda, Tokyo 101-8309, Japan.
Abstract
BACKGROUND: Patients with human papillomavirus (HPV) DNA-positive recurrent laryngeal papillomatosis commonly have repeated recurrences following surgery. The reason is suspected to be a mechanism by which latent HPV infection in the surrounding healthy mucosa reinfects the surgical site. It may be that production of HPV antibodies in the laryngeal mucosa with Gardasil injection could inhibit postoperative recurrence. STUDY DESIGN: This is a case series study. PURPOSE: The purpose of this study was to examine whether Gardasil injection effectively inhibits recurrence. However, as a first report, we describe the antibody titers before and after vaccination. METHODS: Gardasil was injected in 12 men (aged 32-74 years; mean age 47.9 years) with HPV-positive laryngeal papillomatosis. Serum antibody titers of HPV-6, -11, -16, and -18 were measured by a competitive Luminex-based immunoassay before the vaccination and 7 months after the start of the vaccination. RESULTS: Each of the antibody titers was very low before vaccination, and they rose in all patients after the vaccination. CONCLUSIONS: This finding demonstrates that antibody titers increase with Gardasil injection in post-adolescent males.
BACKGROUND:Patients with human papillomavirus (HPV) DNA-positive recurrent laryngeal papillomatosis commonly have repeated recurrences following surgery. The reason is suspected to be a mechanism by which latent HPV infection in the surrounding healthy mucosa reinfects the surgical site. It may be that production of HPV antibodies in the laryngeal mucosa with Gardasil injection could inhibit postoperative recurrence. STUDY DESIGN: This is a case series study. PURPOSE: The purpose of this study was to examine whether Gardasil injection effectively inhibits recurrence. However, as a first report, we describe the antibody titers before and after vaccination. METHODS: Gardasil was injected in 12 men (aged 32-74 years; mean age 47.9 years) with HPV-positive laryngeal papillomatosis. Serum antibody titers of HPV-6, -11, -16, and -18 were measured by a competitive Luminex-based immunoassay before the vaccination and 7 months after the start of the vaccination. RESULTS: Each of the antibody titers was very low before vaccination, and they rose in all patients after the vaccination. CONCLUSIONS: This finding demonstrates that antibody titers increase with Gardasil injection in post-adolescent males.
Authors: Farrel J Buchinsky; Nicole Ruszkay; William Valentino; Craig S Derkay; John E McClay; Robert W Bastian; Charles M Myer; Kevin W Lollar; Dalya Guris Journal: PLoS One Date: 2020-03-11 Impact factor: 3.240
Authors: Charu Aggarwal; Roger B Cohen; Matthew P Morrow; Kimberly A Kraynyak; Albert J Sylvester; Jocelyn Cheung; Kelsie Dickerson; Veronique Schulten; Dawson Knoblock; Elisabeth Gillespie; Joshua M Bauml; Jian Yan; Malissa Diehl; Jean Boyer; Michael Dallas; J Joseph Kim; David B Weiner; Jeffrey M Skolnik Journal: Vaccines (Basel) Date: 2020-01-29