Literature DB >> 27067586

Aggressive basal cell carcinoma of the head and neck: challenges in surgical management.

Peter J F M Lohuis1,2, Anil Joshi3,4, Pepijn A Borggreven2, Lenka Vermeeren2, Biljana Zupan-Kajcovski1, Abrahim Al-Mamgani1, Alfons J M Balm1.   

Abstract

With exponentially increasing numbers of basal cell carcinoma (BCC) of the head and neck region, also the locally advanced BCCs are increasing in number. These tumours are associated with aggressive biological behaviour with invasion of soft tissues, organs or bone and present with wide variation in management strategies. The objectives of the study was to describe the biological behaviour of aggressive BCCs and their clinical presentation in the head and neck region with a series of cases treated in our tertiary hospital, discuss management plans of such complex cases in terms of surgical planning and reconstruction. A series of five cases of aggressive BCC in the head and neck region with involvement of organs such as nose, orbit, temporal bone, facial nerve, paranasal sinuses and mandible was studied. Locally advanced, aggressive BCC should be evaluated and treated as head and neck tumours. Multidisciplinary team (MDT) discussion is advisable wherein the strategies on surgical excision, reconstruction options, facial nerve rehabilitation, indications for prosthesis and further adjuvant treatment such as radiotherapy and chemotherapy are carefully planned.

Entities:  

Keywords:  Aggressive; Basal cell carcinoma; Head and neck; Reconstructive surgery; Skin cancer

Mesh:

Year:  2016        PMID: 27067586     DOI: 10.1007/s00405-016-4039-9

Source DB:  PubMed          Journal:  Eur Arch Otorhinolaryngol        ISSN: 0937-4477            Impact factor:   2.503


  24 in total

1.  A correlation of alpha-smooth muscle actin and invasion in micronodular basal cell carcinoma.

Authors:  M M Christian; R L Moy; R F Wagner; A Yen-Moore
Journal:  Dermatol Surg       Date:  2001-05       Impact factor: 3.398

2.  Gene expression of matrix metalloproteinase-1 (interstitial collagenase) and matrix metalloproteinase-3 (stromelysin-1) in basal cell carcinoma by in situ hybridization using chondroitin ABC lyase.

Authors:  R Tsukifuji; Y Sakai; A Hatamochi; H Shinkai
Journal:  Histochem J       Date:  1997-05

3.  Expression of CXCR4, MMP-13 and β-catenin in different histological subtypes of facial basal cell carcinoma.

Authors:  M E Ciurea; Daniela Cernea; C C Georgescu; O S Cotoi; V Pătraşcu; H Pârvănescu; D Popa; V Pârvănescu; Raluca Niculina Ciurea; R Mercuţ
Journal:  Rom J Morphol Embryol       Date:  2013       Impact factor: 1.033

4.  GDC-0449-a potent inhibitor of the hedgehog pathway.

Authors:  Kirk D Robarge; Shirley A Brunton; Georgette M Castanedo; Yong Cui; Michael S Dina; Richard Goldsmith; Stephen E Gould; Oivin Guichert; Janet L Gunzner; Jason Halladay; Wei Jia; Cyrus Khojasteh; Michael F T Koehler; Karen Kotkow; Hank La; Rebecca L Lalonde; Kevin Lau; Leslie Lee; Derek Marshall; James C Marsters; Lesley J Murray; Changgeng Qian; Lee L Rubin; Laurent Salphati; Mark S Stanley; John H A Stibbard; Daniel P Sutherlin; Savita Ubhayaker; Shumei Wang; Susan Wong; Minli Xie
Journal:  Bioorg Med Chem Lett       Date:  2009-08-15       Impact factor: 2.823

5.  Prediction of aggressive behavior in basal cell carcinoma.

Authors:  G H Jacobs; J J Rippey; M Altini
Journal:  Cancer       Date:  1982-02-01       Impact factor: 6.860

6.  Cutaneous micrographic surgery: Mohs procedure.

Authors:  P K Miller; R K Roenigk; D G Brodland; H W Randle
Journal:  Mayo Clin Proc       Date:  1992-10       Impact factor: 7.616

Review 7.  Basal cell carcinoma. Identification and treatment of the high-risk patient.

Authors:  H W Randle
Journal:  Dermatol Surg       Date:  1996-03       Impact factor: 3.398

Review 8.  Aggressive basal cell carcinoma of head and neck areas.

Authors:  P Vico; T Fourez; E Nemec; G Andry; R Deraemaecker
Journal:  Eur J Surg Oncol       Date:  1995-10       Impact factor: 4.424

9.  Expanded access study of patients with advanced basal cell carcinoma treated with the Hedgehog pathway inhibitor, vismodegib.

Authors:  Anne Lynn S Chang; James A Solomon; John D Hainsworth; Leonard Goldberg; Edward McKenna; Bann-mo Day; Diana M Chen; Glen J Weiss
Journal:  J Am Acad Dermatol       Date:  2013-11-01       Impact factor: 11.527

10.  Trends in incidence of skin basal cell carcinoma. Additional evidence from a UK primary care database study.

Authors:  Fiona Bath-Hextall; Jo Leonardi-Bee; Chris Smith; Andy Meal; Richard Hubbard
Journal:  Int J Cancer       Date:  2007-11-01       Impact factor: 7.396

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