Benedicte Rønning1, Torgeir Bruun Wyller2, Arild Nesbakken3, Eva Skovlund4, Marit Slaaen Jordhøy5, Arne Bakka6, Siri Rostoft7. 1. Department of Geriatric Medicine, Oslo University Hospital, PB 4956, Nydalen, 0424 Oslo, Norway; Faculty of Medicine, University of Oslo, PB 1078, Blindern, 0316 Oslo, Norway. Electronic address: benedronning@gmail.com. 2. Department of Geriatric Medicine, Oslo University Hospital, PB 4956, Nydalen, 0424 Oslo, Norway; Faculty of Medicine, University of Oslo, PB 1078, Blindern, 0316 Oslo, Norway. Electronic address: t.b.wyller@medisin.uio.no. 3. K.G. Jebsen Colorectal Cancer Research Centre, Oslo University Hospital, PB 4956, Nydalen, 0424 Oslo, Norway; Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, PB 1078, Blindern, 0316 Oslo, Norway; Department of Gastrointestinal Surgery, Oslo University Hospital, PB 4956, Nydalen, 0424 Oslo, Norway; Faculty of Medicine, University of Oslo, PB 1078, Blindern, 0316 Oslo, Norway. Electronic address: arild.nesbakken@medisin.uio.no. 4. Department of Public Health and General Practice, Norwegian University of Science and Technology, PB 8905, 7491 Trondheim, Norway. Electronic address: eva.skovlund@ntnu.no. 5. Faculty of Medicine, University of Oslo, PB 1078, Blindern, 0316 Oslo, Norway; Cancer Unit, Innlandet Hospital Trust, PB 104, 2381 Brumunddal, Norway. Electronic address: mjorhoy@gmail.com. 6. Department of Digestive Surgery, Akershus University Hospital, PB 1000, 1478 Lørenskog, Norway. Electronic address: arne.bakka@gmail.com. 7. Department of Geriatric Medicine, Oslo University Hospital, PB 4956, Nydalen, 0424 Oslo, Norway. Electronic address: srostoft@gmail.com.
Abstract
OBJECTIVE: The incidence of colorectal cancer is increasing, mainly due to the aging of the population. Frailty, describing a state of increased vulnerability, is common in older patients, but frailty and high age are not necessarily contraindications to surgical treatment. However, limited data describing long-term outcomes after surgery in this patient group exist. In this clinical follow-up study, we aimed to examine long-term health-related quality of life in older surgical patients with colorectal cancer. MATERIALS AND METHODS: Patients were recruited from a prospective multicenter study investigating frailty as a predictor of postoperative complications after surgery for colorectal cancer. A preoperative geriatric assessment was performed, and patients were classified as frail or non-frail. Patients responded to version 3.0 of The European Organisation of Research and Treatment of Cancer Quality of Life Questionnaire-C30 before surgery, 3months postoperatively and at a long-term follow-up 16-28months (median 22months) after surgery. One-way repeated-measures analyses of variance were performed to examine changes in scores over time. RESULTS: 180 patients with a mean age of 80years were included at baseline, 138 at 3months postoperatively, and 84 patients (69% of survivors) at long-term follow-up. A significant improvement in quality of life-scores was present 3months after surgery, also in the subgroup of frail patients. At long-term follow-up, scores decreased, but to values above baseline. CONCLUSION: Health-related quality of life may be improved in older patients after surgery for colorectal cancer, even in patients who are classified as frail preoperatively.
OBJECTIVE: The incidence of colorectal cancer is increasing, mainly due to the aging of the population. Frailty, describing a state of increased vulnerability, is common in older patients, but frailty and high age are not necessarily contraindications to surgical treatment. However, limited data describing long-term outcomes after surgery in this patient group exist. In this clinical follow-up study, we aimed to examine long-term health-related quality of life in older surgical patients with colorectal cancer. MATERIALS AND METHODS:Patients were recruited from a prospective multicenter study investigating frailty as a predictor of postoperative complications after surgery for colorectal cancer. A preoperative geriatric assessment was performed, and patients were classified as frail or non-frail. Patients responded to version 3.0 of The European Organisation of Research and Treatment of Cancer Quality of Life Questionnaire-C30 before surgery, 3months postoperatively and at a long-term follow-up 16-28months (median 22months) after surgery. One-way repeated-measures analyses of variance were performed to examine changes in scores over time. RESULTS: 180 patients with a mean age of 80years were included at baseline, 138 at 3months postoperatively, and 84 patients (69% of survivors) at long-term follow-up. A significant improvement in quality of life-scores was present 3months after surgery, also in the subgroup of frail patients. At long-term follow-up, scores decreased, but to values above baseline. CONCLUSION: Health-related quality of life may be improved in older patients after surgery for colorectal cancer, even in patients who are classified as frail preoperatively.
Authors: Andrew M Blakely; Dayana Chanson; F Lennie Wong; Oliver S Eng; Stephen M Sentovich; Kurt A Melstrom; Lily L Lai; Yuman Fong; Virginia Sun Journal: Support Care Cancer Date: 2019-11-15 Impact factor: 3.603
Authors: X Serra-Aracil; S Serra-Pla; L Mora-Lopez; A Pallisera-Lloveras; M Labro-Ciurans; S Navarro-Soto Journal: Surg Endosc Date: 2018-06-22 Impact factor: 4.584
Authors: J Knight; K Ayyash; K Colling; J Dhesi; V Ewan; G Danjoux; E Kothmann; A Mill; S Taylor; D Yates; Reema Ayyash Journal: BMC Geriatr Date: 2020-08-27 Impact factor: 3.921