| Literature DB >> 27067437 |
Mahmut Emre Yıldırım1, Umut Kefeli2, Dinçer Aydın3, Nur Sener3, Mahmut Gümüş4.
Abstract
Netrin-1 is found to be elevated and purposive as a diagnostic biomarker in many human cancers. We evaluated serum netrin-1 concentrations in patients with advanced non-small cell lung cancer compared with those in a healthy group. Thirty patients with advanced non-small cell lung cancer and 30 healthy people were included in the study. Serum netrin-1 concentrations were measured by quantitative ELISA method in both groups. The mean serum netrin-1 concentrations were found to be significantly higher in patients with non-small cell lung cancer than in healthy controls. The mean serum netrin-1 concentrations were found to be significantly higher in patients with non-small cell lung cancer before the beginning of chemotherapy when compared after the completion of the third cycle. Our results represented that netrin-1 concentrations elevated in advanced non-small cell lung cancer compared to a healthy control group, and netrin-1 concentrations decreased with chemotherapy.Entities:
Keywords: Biomarker; Gastric cancer; Netrin-1; Treatment
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Year: 2016 PMID： 27067437 DOI： 10.1007/s13277-016-5025-y
Source DB: PubMed Journal: Tumour Biol ISSN： 1010-4283