Literature DB >> 27067331

Elucidation of Mechanisms of Ceftazidime Resistance among Clinical Isolates of Pseudomonas aeruginosa by Using Genomic Data.

Veronica N Kos1, Robert E McLaughlin2, Humphrey A Gardner3.   

Abstract

Ceftazidime is one of the few cephalosporins with activity against Pseudomonas aeruginosa Using whole-genome comparative analysis, we set out to determine the prevalent mechanism(s) of resistance to ceftazidime (CAZ) using a set of 181 clinical isolates. These isolates represented various multilocus sequence types that consisted of both ceftazidime-susceptible and -resistant populations. A presumptive resistance mechanism against ceftazidime was identified in 88% of the nonsusceptible isolates using this approach.
Copyright © 2016, American Society for Microbiology. All Rights Reserved.

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Year:  2016        PMID： 27067331      PMCID： PMC4879354          DOI： 10.1128/AAC.03113-15

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  29 in total

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3.  Susceptibility to beta-lactam antibiotics of Pseudomonas aeruginosa overproducing penicillin-binding protein 3.

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Review 4.  Pseudomonas aeruginosa: resistance and therapeutic options at the turn of the new millennium.

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7.  Molecular epidemiology of metallo-beta-lactamase-producing Pseudomonas aeruginosa isolates from Norway and Sweden shows import of international clones and local clonal expansion.

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Journal:  Antimicrob Agents Chemother       Date:  2009-11-02       Impact factor: 5.191

8.  Mode of action of ceftazidime: affinity for the penicillin-binding proteins of Escherichia coli K12, Pseudomonas aeruginosa and Staphylococcus aureus.

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  6 in total

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Journal:  Clin Infect Dis       Date:  2017-09-01       Impact factor: 9.079

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Journal:  Antimicrob Agents Chemother       Date:  2022-09-06       Impact factor: 5.938

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Journal:  PLoS One       Date:  2017-06-28       Impact factor: 3.240

4.  Identifying genetic determinants of complex phenotypes from whole genome sequence data.

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Journal:  BMC Genomics       Date:  2019-06-10       Impact factor: 3.969

5.  Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening.

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6.  Inducible cellulase production from an organic solvent tolerant Bacillus sp. SV1 and evolutionary divergence of endoglucanase in different species of the genus Bacillus.

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  6 in total

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