Robert Z Tashjian1, Erin K Granger2, Yue Zhang3, Craig C Teerlink4, Lisa A Cannon-Albright5. 1. Department of Orthopaedics, University of Utah School of Medicine, Salt Lake City, UT, USA; George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, USA. Electronic address: Robert.Tashjian@hsc.utah.edu. 2. Department of Orthopaedics, University of Utah School of Medicine, Salt Lake City, UT, USA. 3. Division of Epidemiology, Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA. 4. Division of Genetic Epidemiology, Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA. 5. George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, USA; Division of Genetic Epidemiology, Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA.
Abstract
BACKGROUND: A familial and genetic predisposition for the development of rotator cuff tearing has been identified. The purpose of this study was to determine if a familial predisposition exists for healing after rotator cuff repair and if the reported significant association with a single-nucleotide polymorphism (SNP) in the ESRRB gene is present in patients who fail to heal. MATERIALS AND METHODS: The study recruited 72 patients undergoing arthroscopic rotator cuff repair for a full-thickness posterosuperior tear. Magnetic resonance imaging studies were performed at a minimum of 1 year postoperatively (average, 2.6 years). Healing failures were classified as lateral or medial. Self-reported family history of rotator cuff tearing data and genome-wide genotypes were available. Characteristics of cases with and without a family history of rotator cuff tearing were compared, and a comparison of the frequency of SNP 1758384 (in ESRRB) was performed between patients who healed and those who failed to heal. RESULTS: Of the rotator cuff repairs, 42% failed to heal; 42% of patients reported a family history of rotator cuff tear. Multivariate regression analysis showed a significant association between familiality and overall healing failure (medial and lateral failures) (P = .036) and lateral failures independently (P = .006). An increased risk for the presence of a rare allele for SNP rs17583842 was present in lateral failures compared with those that healed (P = .005). CONCLUSIONS: Individuals with a family history of rotator cuff tearing were more likely to have repair failures. Significant association of a SNP variant in the ESRRB gene was also observed with lateral failure.
BACKGROUND: A familial and genetic predisposition for the development of rotator cuff tearing has been identified. The purpose of this study was to determine if a familial predisposition exists for healing after rotator cuff repair and if the reported significant association with a single-nucleotide polymorphism (SNP) in the ESRRB gene is present in patients who fail to heal. MATERIALS AND METHODS: The study recruited 72 patients undergoing arthroscopic rotator cuff repair for a full-thickness posterosuperior tear. Magnetic resonance imaging studies were performed at a minimum of 1 year postoperatively (average, 2.6 years). Healing failures were classified as lateral or medial. Self-reported family history of rotator cuff tearing data and genome-wide genotypes were available. Characteristics of cases with and without a family history of rotator cuff tearing were compared, and a comparison of the frequency of SNP 1758384 (in ESRRB) was performed between patients who healed and those who failed to heal. RESULTS: Of the rotator cuff repairs, 42% failed to heal; 42% of patients reported a family history of rotator cuff tear. Multivariate regression analysis showed a significant association between familiality and overall healing failure (medial and lateral failures) (P = .036) and lateral failures independently (P = .006). An increased risk for the presence of a rare allele for SNP rs17583842 was present in lateral failures compared with those that healed (P = .005). CONCLUSIONS: Individuals with a family history of rotator cuff tearing were more likely to have repair failures. Significant association of a SNP variant in the ESRRB gene was also observed with lateral failure.
Authors: Elizabeth L Yanik; Jay D Keener; Shiow J Lin; Graham A Colditz; Rick W Wright; Bradley A Evanoff; Nitin B Jain; Nancy L Saccone Journal: J Bone Joint Surg Am Date: 2021-07-21 Impact factor: 6.558
Authors: Karch M Smith; Angela P Presson; Chong Zhang; Joshua J Horns; James M Hotaling; Robert Z Tashjian; Peter N Chalmers Journal: JSES Int Date: 2021-04-20