S T Skou1, B L Wise2, C E Lewis3, D Felson4, M Nevitt5, N A Segal6. 1. Research Unit for Musculoskeletal Function and Physiotherapy, Institute of Sports Science and Clinical Biomechanics, University of Southern Denmark, Denmark; Clinical Nursing Research Unit, Aalborg University Hospital, Aalborg, Denmark. Electronic address: stskou@health.sdu.dk. 2. Center for Musculoskeletal Health, University of California, Davis School of Medicine, Sacramento, CA, USA. Electronic address: barton.wise@ucdmc.ucdavis.edu. 3. University of Alabama at Birmingham, Birmingham, AL, United States. Electronic address: celewis@uabmc.edu. 4. Boston University School of Medicine, Boston, MA, United States. Electronic address: dfelson@bu.edu. 5. University of California, San Francisco, San Francisco, CA, United States. Electronic address: mnevitt@psg.ucsf.edu. 6. University of Kansas, Kansas City, KS, United States. Electronic address: neil-segal@uiowa.edu.
Abstract
OBJECTIVE: To investigate associations between lower levels of muscle strength, physical performance and physical activity and the risk of knee replacement (KR) in older adults with frequent knee pain. METHOD: Participants from the Multicenter Osteoarthritis Study (MOST) with knee pain on most of the past 30 days at baseline were included (n = 1257; mean (SD) age of 62.2 (8.2)). We examined the association between (1) baseline peak isokinetic knee extensor strength, (60°/sec, maximum out of four trials), (2) best time to stand in timed chair stand (2 trials of five repetitions), and (3) baseline Physical Activity Scale for the Elderly score (PASE) with incident KR between baseline and the 84-month follow-up. RESULTS: 1252 (99.6%) participants (1682 knees) completed the follow-up visits. 331 participants (394 knees) underwent a KR during the 84 months (229 women and 102 men). The crude analysis demonstrated a decreased risk of KR in women (P < 0.0001) with higher knee extensor strength (Hazard Ratio (HR; 95% CI) 0.99 (0.98-0.99)). The risk remained significant (P = 0.03) when adjusting for age, BMI, race, clinic site, education, occupation, previous knee injury, previous knee surgery, and WOMAC pain (HR (95% CI) 0.99 (0.99-1.00)), but not when adjusting for Kellgren-Lawrence grade (P = 0.97). CONCLUSION: Lower levels of chair stand performance and self-reported physical activity are not associated with an increased risk of KR within 7 years, while the independent effect of knee extensor strength on risk for KR in women is non-significant after adjusting for radiographic severity.
OBJECTIVE: To investigate associations between lower levels of muscle strength, physical performance and physical activity and the risk of knee replacement (KR) in older adults with frequent knee pain. METHOD:Participants from the Multicenter Osteoarthritis Study (MOST) with knee pain on most of the past 30 days at baseline were included (n = 1257; mean (SD) age of 62.2 (8.2)). We examined the association between (1) baseline peak isokinetic knee extensor strength, (60°/sec, maximum out of four trials), (2) best time to stand in timed chair stand (2 trials of five repetitions), and (3) baseline Physical Activity Scale for the Elderly score (PASE) with incident KR between baseline and the 84-month follow-up. RESULTS: 1252 (99.6%) participants (1682 knees) completed the follow-up visits. 331 participants (394 knees) underwent a KR during the 84 months (229 women and 102 men). The crude analysis demonstrated a decreased risk of KR in women (P < 0.0001) with higher knee extensor strength (Hazard Ratio (HR; 95% CI) 0.99 (0.98-0.99)). The risk remained significant (P = 0.03) when adjusting for age, BMI, race, clinic site, education, occupation, previous knee injury, previous knee surgery, and WOMAC pain (HR (95% CI) 0.99 (0.99-1.00)), but not when adjusting for Kellgren-Lawrence grade (P = 0.97). CONCLUSION: Lower levels of chair stand performance and self-reported physical activity are not associated with an increased risk of KR within 7 years, while the independent effect of knee extensor strength on risk for KR in women is non-significant after adjusting for radiographic severity.
Authors: N A Segal; N A Glass; J Torner; M Yang; D T Felson; L Sharma; M Nevitt; C E Lewis Journal: Osteoarthritis Cartilage Date: 2010-02-11 Impact factor: 6.576
Authors: Barton L Wise; Jingbo Niu; David T Felson; Jean Hietpas; Alesia Sadosky; James Torner; Cora E Lewis; Michael Nevitt Journal: Clin Orthop Relat Res Date: 2015-08 Impact factor: 4.176
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Authors: Daniel K White; Catrine Tudor-Locke; Yuqing Zhang; Roger Fielding; Michael LaValley; David T Felson; K Douglas Gross; Michael C Nevitt; Cora E Lewis; James Torner; Tuhina Neogi Journal: Arthritis Care Res (Hoboken) Date: 2014-09 Impact factor: 4.794
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Authors: Richard P Troiano; David Berrigan; Kevin W Dodd; Louise C Mâsse; Timothy Tilert; Margaret McDowell Journal: Med Sci Sports Exerc Date: 2008-01 Impact factor: 5.411
Authors: N A Glass; J C Torner; L A Frey Law; K Wang; T Yang; M C Nevitt; D T Felson; C E Lewis; N A Segal Journal: Osteoarthritis Cartilage Date: 2013-09 Impact factor: 6.576
Authors: Bo Hu; Søren Thorgaard Skou; Barton L Wise; Glenn N Williams; Michael C Nevitt; Neil A Segal Journal: Arch Phys Med Rehabil Date: 2018-01-31 Impact factor: 3.966
Authors: M L Fitzgibbon; L Tussing-Humphreys; L Schiffer; R Smith-Ray; A D Demott; M Martinez; M L Berbaum; G M Huber; S L Hughes Journal: J Aging Res Clin Pract Date: 2018
Authors: Hiral Master; Louise M Thoma; Tuhina Neogi; Dorothy D Dunlop; Michael LaValley; Meredith B Christiansen; Dana Voinier; Daniel K White Journal: Arch Phys Med Rehabil Date: 2021-06-24 Impact factor: 4.060