Jean-Mari Kriek1, Shameem Z Jaumdally1, Lindi Masson1, Francesca Little2, Zizipho Mbulawa3, Pamela P Gumbi1, Shaun L Barnabas4, Jennifer Moodley5, Lynette Denny6, David Coetzee7, Anna-Lise Williamson8, Jo-Ann S Passmore9. 1. Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa. 2. Department of Statistical Science, University of Cape Town, Cape Town, South Africa. 3. Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; Center for HIV and STIs National Institute for Communicable Disease, National Health Laboratory Service, South Africa. 4. Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; Desmond Tutu HIV Foundation, University of Cape Town, Cape Town, South Africa. 5. UCT/MRC Clinical Gynaecological Cancer Research Centre, University of Cape Town, Cape Town, South Africa; Cancer Research Initiative, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; Women׳s Health Research Unit, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa. 6. UCT/MRC Clinical Gynaecological Cancer Research Centre, University of Cape Town, Cape Town, South Africa; Department of Obstetrics and Gynaecology, University of Cape Town/Groote Schuur Hospital, Cape Town, South Africa. 7. School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa. 8. Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; UCT/MRC Clinical Gynaecological Cancer Research Centre, University of Cape Town, Cape Town, South Africa; National Health Laboratory Service, South Africa. 9. Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; UCT/MRC Clinical Gynaecological Cancer Research Centre, University of Cape Town, Cape Town, South Africa; National Health Laboratory Service, South Africa. Electronic address: Jo-ann.Passmore@uct.ac.za.
Abstract
BACKGROUND: Persistent genital infections with high-risk HPV types increase risk of cervical disease and cancer. Since genital inflammation increases HIV acquisition risk and cancer progression, we evaluated whether HPV infection induces cytokine expression in the reproductive tract. METHODS: Genital cytokines concentrations were measured in 93 HIV-infected and 72 uninfected women. HPV typing was done by Roche Linear array. Persistence and clearance of HPV were evaluated using longitudinal data. RESULTS: Infection with HPV did not influence genital cytokine concentrations. In contrast, HIV-infected women had higher IL-1α, IL-6, IL-8, IP-10, MCP-1 and G-CSF concentrations compared to HIV-uninfected women, and HPV-infections that were more prevalent, persistent and multi-type. CONCLUSION: HPV did not influence inflammatory cytokine levels in the genital tract, although immune suppression may favor persistence.
BACKGROUND: Persistent genital infections with high-risk HPV types increase risk of cervical disease and cancer. Since genital inflammation increases HIV acquisition risk and cancer progression, we evaluated whether HPV infection induces cytokine expression in the reproductive tract. METHODS: Genital cytokines concentrations were measured in 93 HIV-infected and 72 uninfected women. HPV typing was done by Roche Linear array. Persistence and clearance of HPV were evaluated using longitudinal data. RESULTS: Infection with HPV did not influence genital cytokine concentrations. In contrast, HIV-infectedwomen had higher IL-1α, IL-6, IL-8, IP-10, MCP-1 and G-CSF concentrations compared to HIV-uninfectedwomen, and HPV-infections that were more prevalent, persistent and multi-type. CONCLUSION:HPV did not influence inflammatory cytokine levels in the genital tract, although immune suppression may favor persistence.
Authors: B Shannon; T J Yi; S Perusini; P Gajer; B Ma; M S Humphrys; J Thomas-Pavanel; L Chieza; P Janakiram; M Saunders; W Tharao; S Huibner; K Shahabi; J Ravel; A Rebbapragada; R Kaul Journal: Mucosal Immunol Date: 2017-01-25 Impact factor: 7.313
Authors: Gulcin Tezcan; Ekaterina V Martynova; Zarema E Gilazieva; Alan McIntyre; Albert A Rizvanov; Svetlana F Khaiboullina Journal: Front Pharmacol Date: 2019-05-01 Impact factor: 5.810
Authors: Alan Messala A Britto; Livia R Goes; Aida Sivro; Cintia Policarpo; Ângela R Meirelles; Yara Furtado; Gutemberg Almeida; James Arthos; Claudia Cicala; Marcelo A Soares; Elizabeth S Machado; Ana Lúcia M Giannini Journal: Front Immunol Date: 2020-09-03 Impact factor: 7.561