| Literature DB >> 2706501 |
P J Williams1, B A MacVicar, Q J Pittman.
Abstract
Intracellular recordings from melanotrophs in acutely isolated, intact pituitaries revealed inhibitory postsynaptic potentials (IPSPs) resulting from both pituitary stalk stimulation and exogenous gamma-aminobutyric acid (GABA) application. The stalk-stimulated and GABA-evoked IPSPs displayed identical conductance increases to chloride ions. Both responses reversed in polarity at the same membrane potential and were blocked with bicuculline, a GABAA antagonist. We conclude that activation of this synapse releases GABA which acts on a classical GABAA receptor to increase conductance to chloride in the melanotroph.Entities:
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Year: 1989 PMID： 2706501 DOI： 10.1016/0006-8993(89)90043-7
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252