Meng-Rui Lee1,2,3,4, Chia-Jung Tsai4, Jia-Ying Hu4, Shih-Wei Lee4, Jen-Chung Ko1, Hao-Chien Wang2, Chong-Jen Yu2, Li-Na Lee2,5, Po-Ren Hsueh2,5. 1. Department of Internal Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu, Taiwan. 2. Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan. 3. Institute of Preventive Epidemiology & Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan. 4. Department of Internal Medicine, Taoyuan General Hospital, Ministry of Health & Welfare, Taoyuan City, Taiwan. 5. Department of Laboratory Medicine, National Taiwan University College of Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Abstract
AIM: To investigate the acquisition of Mycobacterium abscessus among ventilator-dependent patients. MATERIALS & METHODS: We prospectively recruited ventilator-dependent patients in five respiratory care wards (RCWs). Respiratory specimens were cultured for mycobacteria on day 1 (D1), 3 months (M3) and 6 months (M6) after enrollment. RESULTS: 72 patients had cultures taken at all three time points. The proportion of patients with a culture positive for M. abscessus increased from 15.3% (11/72) on D1 to 30.6% (22/72) at M3 and 38.9% (28/72) at M6. Two M. abscessus subspecies abscessus isolates obtained from different patients had identical randomly amplified polymorphic DNA patterns. Being in RCW D and advanced age were significantly associated with initial cultures positivity. CONCLUSION: Our study reveals that acquisition of M. abscessus was common among ventilator-dependent patients.
AIM: To investigate the acquisition of Mycobacterium abscessus among ventilator-dependent patients. MATERIALS & METHODS: We prospectively recruited ventilator-dependent patients in five respiratory care wards (RCWs). Respiratory specimens were cultured for mycobacteria on day 1 (D1), 3 months (M3) and 6 months (M6) after enrollment. RESULTS: 72 patients had cultures taken at all three time points. The proportion of patients with a culture positive for M. abscessus increased from 15.3% (11/72) on D1 to 30.6% (22/72) at M3 and 38.9% (28/72) at M6. Two M. abscessus subspecies abscessus isolates obtained from different patients had identical randomly amplified polymorphic DNA patterns. Being in RCW D and advanced age were significantly associated with initial cultures positivity. CONCLUSION: Our study reveals that acquisition of M. abscessus was common among ventilator-dependent patients.
Entities:
Keywords:
M. abscessus; M. abscessus subspecies abscessus; M. abscessus subspecies massiliense; Taiwan; chronic respiratory care wards; dendrogram; nontuberculous mycobacteria; ventilator-dependent patients