Literature DB >> 2706415

Podophyllum derivatives (CPH 82) compared with placebo in the treatment of rheumatoid arthritis.

A Larsen1, I Petersson, B Svensson.   

Abstract

The efficacy, tolerance, and safety of CPH 82 (semisynthetic lignan glycosides) (Conpharm AB) for patients with rheumatoid arthritis (RA) were assessed in a 12-week double-blind placebo-controlled study. Thirteen patients out of 15 in the CPH 82 group and 10 out of 15 in the placebo group completed the study. No improvement was seen in placebo treated patients. Patients treated with CPH 82 showed a statistically significant improvement in most clinical and immunological variables. Some patients treated with CPH 82 reported gastrointestinal discomfort (diarrhoea and abdominal pain).

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Year:  1989        PMID: 2706415     DOI: 10.1093/rheumatology/28.2.124

Source DB:  PubMed          Journal:  Br J Rheumatol        ISSN: 0263-7103


  4 in total

Review 1.  Rheumatology.

Authors:  R A Asherson; R Cervera; D P D'Cruz; G R Hughes
Journal:  Postgrad Med J       Date:  1991-02       Impact factor: 2.401

2.  Effect of CPH82 in rheumatoid arthritis. Accumulation of bone marrow cells in mitosis and clinical response.

Authors:  S Rantapää-Dahlqvist; E Löfvenbert; B Norberg
Journal:  Clin Rheumatol       Date:  1993-12       Impact factor: 2.980

3.  Chromosomal changes in rheumatoid arthritis patients treated with CPH82.

Authors:  S Rantapää Dahlqvist; I Nordenson
Journal:  Clin Rheumatol       Date:  1996-11       Impact factor: 2.980

4.  Biological Activity of N-Hydroxyethyl-4-aza-2,3-didehydropodophyllotoxin Derivatives upon Colorectal Adenocarcinoma Cells.

Authors:  Christian Vélez; Beatriz Zayas; Ajay Kumar
Journal:  Open J Med Chem       Date:  2014-03
  4 in total

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