| Literature DB >> 27063846 |
Cinzia Ferrario1, Livio Leggio2, Roberta Leone3, Cristiano Di Benedetto4, Luca Guidetti5, Valentina Coccè6, Miriam Ascagni7, Francesco Bonasoro8, Caterina A M La Porta9, M Daniela Candia Carnevali10, Michela Sugni11.
Abstract
The use of marine collagens is a hot topic in the field of tissue engineering. Echinoderms possess unique connective tissues (Mutable Collagenous Tissues, MCTs) which can represent an innovative source of collagen to develop collagen barrier-membranes for Guided Tissue Regeneration (GTR). In the present work we used MCTs from different echinoderm models (sea urchin, starfish and sea cucumber) to produce echinoderm-derived collagen membranes (EDCMs). Commercial membranes for GTR or soluble/reassembled (fibrillar) bovine collagen substrates were used as controls. The three EDCMs were similar among each other in terms of structure and mechanical performances and were much thinner and mechanically more resistant than the commercial membranes. Number of fibroblasts seeded on sea-urchin membranes were comparable to the bovine collagen substrates. Cell morphology on all EDCMs was similar to that of structurally comparable (reassembled) bovine collagen substrates. Overall, echinoderms, and sea urchins particularly, are alternative collagen sources to produce efficient GTR membranes. Sea urchins display a further advantage in terms of eco-sustainability by recycling tissues from food wastes.Entities:
Keywords: Alternative biomaterial; By-product valorisation; Echinoderms; Environmental impact; Guided tissue regeneration; Human fibroblast culture; Marine collagen; Mutable collagenous tissues; “Blue” biotechnology
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Year: 2016 PMID： 27063846 DOI： 10.1016/j.marenvres.2016.03.007
Source DB: PubMed Journal: Mar Environ Res ISSN： 0141-1136 Impact factor: 3.130