Literature DB >> 27063668

Neurotrophic factors and their inhibitors in chronic pain treatment.

Jayne H Kelleher1, Damini Tewari2, Stephen B McMahon2.   

Abstract

Chronic pain affects more than 20% of the UK population. Neurotrophic factors have been identified as therapeutic targets to improve current treatments of chronic pain. This review article focuses on nerve growth factor (NGF) and interleukin-6 (IL-6) as potential therapeutic targets. In this review we highlight the mechanisms of action and the current progress of targeted therapies in clinical trials.
Copyright © 2016 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Clinical trial; IL6; NGF; Pain

Mesh：

Substances：

Year:  2016        PMID： 27063668     DOI： 10.1016/j.nbd.2016.03.025

Source DB:  PubMed          Journal:  Neurobiol Dis        ISSN： 0969-9961            Impact factor:   5.996


  13 in total

Review 1.  Mast cell-neural interactions contribute to pain and itch.

Authors:  Kalpna Gupta; Ilkka T Harvima
Journal:  Immunol Rev       Date:  2018-03       Impact factor: 12.988

Review 2.  Nerve growth factor: a neuroimmune crosstalk mediator for all seasons.

Authors:  Stephen D Skaper
Journal:  Immunology       Date:  2017-02-21       Impact factor: 7.397

3.  Conformational Rigidity within Plasticity Promotes Differential Target Recognition of Nerve Growth Factor.

Authors:  Francesca Paoletti; Cesira de Chiara; Geoff Kelly; Sonia Covaceuszach; Francesca Malerba; Robert Yan; Doriano Lamba; Antonino Cattaneo; Annalisa Pastore
Journal:  Front Mol Biosci       Date:  2016-12-26

Review 4.  An Inflammation-Centric View of Neurological Disease: Beyond the Neuron.

Authors:  Stephen D Skaper; Laura Facci; Morena Zusso; Pietro Giusti
Journal:  Front Cell Neurosci       Date:  2018-03-21       Impact factor: 5.505

5.  Rib soft fixation produces better analgesic effects and is associated with cytokine changes within the spinal cord in a rat rib fracture model.

Authors:  Yuan-Yuarn Liu; Jeffrey Chi-Fei Wang; Ya-Chi Lin; Hung-Tsung Hsiao; Yen-Chin Liu
Journal:  Mol Pain       Date:  2019 Jan-Dec       Impact factor: 3.395

Review 6.  Cyclooxygenase-2 in Endometriosis.

Authors:  Zhen-Zhen Lai; Hui-Li Yang; Si-Yao Ha; Kai-Kai Chang; Jie Mei; We-Jie Zhou; Xue-Min Qiu; Xiao-Qiu Wang; Rui Zhu; Da-Jin Li; Ming-Qing Li
Journal:  Int J Biol Sci       Date:  2019-10-23       Impact factor: 6.580

7.  Neuritin-overexpressing transgenic mice demonstrate enhanced neuroregeneration capacity and improved spatial learning and memory recovery after ischemia-reperfusion injury.

Authors:  Kexing Wan; Fuxiu Mao; Qiongqiong Li; Limin Wang; Zhiguo Wei; Ping Wang; Xinhua Liao; Mengsi Xu; Jin Huang; Zemin Pan; Chengtan Wang; Jian Luo; Rui Gao; Shangquan Gan
Journal:  Aging (Albany NY)       Date:  2020-12-15       Impact factor: 5.682

8.  Toll-like Receptor Activation Induces Degeneration of Human Intervertebral Discs.

Authors:  Emerson Krock; Derek H Rosenzweig; J Brooke Currie; Daniel G Bisson; Jean A Ouellet; Lisbet Haglund
Journal:  Sci Rep       Date:  2017-12-07       Impact factor: 4.379

9.  Peripheral inflammatory pain sensitisation is independent of mast cell activation in male mice.

Authors:  Douglas M Lopes; Franziska Denk; Kim I Chisholm; Tesha Suddason; Camille Durrieux; Matthew Thakur; Clive Gentry; Stephen B McMahon
Journal:  Pain       Date:  2017-07       Impact factor: 7.926

10.  Accumulation of Cav3.2 T-type Calcium Channels in the Uninjured Sural Nerve Contributes to Neuropathic Pain in Rats with Spared Nerve Injury.

Authors:  Wen Chen; Ye-Nan Chi; Xue-Jing Kang; Qing-Ying Liu; Hao-Lin Zhang; Zhi-Hua Li; Zi-Fang Zhao; Yin Yang; Li Su; Jie Cai; Fei-Fei Liao; Ming Yi; You Wan; Feng-Yu Liu
Journal:  Front Mol Neurosci       Date:  2018-02-08       Impact factor: 5.639
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