J I Rojas1, L Patrucco2, J MIguez2, V Sinay3, F Pagani Cassara3, F Cáceres4, N Fernandez Liguori5, M L Saladino5, N Deri6, G Jaacks6, M Parada Marcilla7, M I Arrigoni8, J Correale9, M Fiol9, M C Ysrraelit9, A Carrá10, M C Curbelo10, A Martinez10, J Steinberg10, S Bestoso11, J P Hryb12, J L Di Pace12, M B Perassolo12, E Carnero Contentti13, A Caride13, P A Lopez13, C Martinez7, E Reich14, E Cristiano2. 1. Centro de Esclerosis Múltiple de Buenos Aires, Hospital Italiano de Buenos Aires, Argentina. Electronic address: juan.rojas@hospitalitaliano.org.ar. 2. Centro de Esclerosis Múltiple de Buenos Aires, Hospital Italiano de Buenos Aires, Argentina. 3. Instituto de Neurociencias, Fundación Favaloro, Argentina. 4. Neurosciences Institute of Buenos Aires (INEBA), Buenos Aires, Argentina. 5. Neurosciences Institute of Buenos Aires (INEBA), Buenos Aires, Argentina; Multiple Sclerosis Section Hospital E.Tornú, Buenos Aires, Argentina. 6. Centro de Investigación DIABAID, Argentina. 7. Private Office, Private Office, Argentina. 8. Hospital Italiano de Córdoba, Argentina. 9. Department of Neurology, Institute for Neurological Research Dr. Raúl Carrea, FLENI, Argentina. 10. Hospital Británico Buenos Aires, Argentina. 11. Hospital Escuela "José F. De San Martín", Corrientes, Argentina. 12. Hospital General de Agudos Carlos G Durand, Buenos Aires, Argentina. 13. Hospital Alemán, Buenos Aires, Argentina. 14. Hospital Julio Mendez, Buenos Aires, Argentina.
Abstract
UNLABELLED: The present study was carried out to assess if there is an anticipation of age at onset in younger generations of familial multiple sclerosis (FMS) vs. sporadic MS (SMS) in Argentina. METHODS: multicenter study that included patients from 14 MS Centers of Argentina. Patients were considered as FMS if they had in their family at least one relative of first or second degree diagnosed with MS; otherwise, patients were considered to have SMS. We compared the age at onset between familial and sporadic cases as well as the age at onset between relatives from different generations in FMS vs. SMS. RESULTS: 1333 patients were included, 97 of them were FMS (7.3%). A lower age at onset in the younger generations of FMS cases was found compared with older generations of FMS as well as. SMS cases (24.1±3.7 years vs. 30.3±5.7 years, and 32.4±9.4 respectively; p<0.001). No differences were observed between older generations of FMS vs. SMS cases (p=0.12). CONCLUSION: we observed an anticipation of age at onset of MS in younger generations of patients with FMS vs. older generations of FMS and SMS.
UNLABELLED: The present study was carried out to assess if there is an anticipation of age at onset in younger generations of familial multiple sclerosis (FMS) vs. sporadic MS (SMS) in Argentina. METHODS: multicenter study that included patients from 14 MS Centers of Argentina. Patients were considered as FMS if they had in their family at least one relative of first or second degree diagnosed with MS; otherwise, patients were considered to have SMS. We compared the age at onset between familial and sporadic cases as well as the age at onset between relatives from different generations in FMS vs. SMS. RESULTS: 1333 patients were included, 97 of them were FMS (7.3%). A lower age at onset in the younger generations of FMS cases was found compared with older generations of FMS as well as. SMS cases (24.1±3.7 years vs. 30.3±5.7 years, and 32.4±9.4 respectively; p<0.001). No differences were observed between older generations of FMS vs. SMS cases (p=0.12). CONCLUSION: we observed an anticipation of age at onset of MS in younger generations of patients with FMS vs. older generations of FMS and SMS.
Authors: Andres G Barboza; Edgar Carnero Contentti; Maria Celeste Curbelo; Mario Javier Halfon; Juan Ignacio Rojas; Berenice A Silva; Vladimiro Sinay; Santiago Tizio; Maria Celica Ysrraelit; Ricardo Alonso Journal: Neurol Sci Date: 2021-01-25 Impact factor: 3.307