Literature DB >> 27062494

Neurons exhibit Lyz2 promoter activity in vivo: Implications for using LysM-Cre mice in myeloid cell research.

Johannes Orthgiess1, Martin Gericke2, Kerstin Immig2, Angela Schulz3, Johannes Hirrlinger1, Ingo Bechmann2, Jens Eilers1.   

Abstract

To characterize LysM-Cre mediated gene targeting in mice, we crossed LysM-Cre mice to two independent reporter-mouse lines (tdTomato or YFP). Surprisingly, we found that more than 90% of cells with LysM-Cre mediated recombination in the brain were neurons, rather than myeloid cells, such as microglia. Hence, by using the LysM-Cre mouse line for conditional knockout approaches, a significant neuronal recombination needs to be considered.
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  Brain; LysM-Cre; Lyz2; Microglia; Neuroinflammation; Neurons

Mesh：

Substances：

Year:  2016        PMID： 27062494     DOI： 10.1002/eji.201546108

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN： 0014-2980            Impact factor:   5.532


  41 in total

1.  Glucocorticoids Have Opposing Effects on Liver Fibrosis in Hepatic Stellate and Immune Cells.

Authors:  Kang Ho Kim; Jae Man Lee; Ying Zhou; Sanjiv Harpavat; David D Moore
Journal:  Mol Endocrinol       Date:  2016-06-29

2.  Loss of Antigen Presentation in Adipose Tissue Macrophages or in Adipocytes, but Not Both, Improves Glucose Metabolism.

Authors:  Alecia M Blaszczak; Valerie P Wright; Kajol Anandani; Joey Liu; Anahita Jalilvand; Stephen Bergin; Sarah M Nicoloro; Michael P Czech; William Lafuse; Tuo Deng; David Bradley; Willa A Hsueh
Journal:  J Immunol       Date:  2019-03-08       Impact factor: 5.422

Review 3.  The influence of environment and origin on brain resident macrophages and implications for therapy.

Authors:  Mariko L Bennett; F Chris Bennett
Journal:  Nat Neurosci       Date:  2019-12-02       Impact factor: 24.884

4.  Protein arginine methyltransferase 1 modulates innate immune responses through regulation of peroxisome proliferator-activated receptor γ-dependent macrophage differentiation.

Authors:  Irina Tikhanovich; Jie Zhao; Jody Olson; Abby Adams; Ryan Taylor; Brian Bridges; Laurie Marshall; Benjamin Roberts; Steven A Weinman
Journal:  J Biol Chem       Date:  2017-03-22       Impact factor: 5.157

5.  Increased levels of Gab1 and Gab2 adaptor proteins skew interleukin-4 (IL-4) signaling toward M2 macrophage-driven pulmonary fibrosis in mice.

Authors:  Xiaohong Guo; Tingting Li; Yun Xu; Xiayan Xu; Zhengyi Zhu; Yun Zhang; Jiaqi Xu; Kaihong Xu; Hongqiang Cheng; Xue Zhang; Yuehai Ke
Journal:  J Biol Chem       Date:  2017-07-07       Impact factor: 5.157

6.  Opposing Functions of Microglial and Macrophagic TNFR2 in the Pathogenesis of Experimental Autoimmune Encephalomyelitis.

Authors:  Han Gao; Matt C Danzi; Claire S Choi; Mehran Taherian; Camilla Dalby-Hansen; Ditte G Ellman; Pernille M Madsen; John L Bixby; Vance P Lemmon; Kate L Lambertsen; Roberta Brambilla
Journal:  Cell Rep       Date:  2017-01-03       Impact factor: 9.423

7.  Toll-like receptor mediated lysozyme expression in Niemann-pick disease, type C1.

Authors:  Antony Cougnoux; Julia C Yerger; Mason Fellmeth; Jenny Serra-Vinardell; Christopher A Wassif; Niamh X Cawley; Forbes D Porter
Journal:  Mol Genet Metab       Date:  2020-10-18       Impact factor: 4.797

8.  Type I Interferon Signaling to Dendritic Cells Limits Murid Herpesvirus 4 Spread from the Olfactory Epithelium.

Authors:  Clara Lawler; Philip G Stevenson
Journal:  J Virol       Date:  2017-11-14       Impact factor: 5.103

9.  Cell-Type-Specific Interleukin 1 Receptor 1 Signaling in the Brain Regulates Distinct Neuroimmune Activities.

Authors:  Xiaoyu Liu; Daniel P Nemeth; Daniel B McKim; Ling Zhu; Damon J DiSabato; Olimpia Berdysz; Gowthami Gorantla; Braedan Oliver; Kristina G Witcher; Yufen Wang; Christina E Negray; Rekha S Vegesna; John F Sheridan; Jonathan P Godbout; Matthew J Robson; Randy D Blakely; Phillip G Popovich; Staci D Bilbo; Ning Quan
Journal:  Immunity       Date:  2019-01-22       Impact factor: 31.745

Review 10.  Contributions of innate type 2 inflammation to adipose function.

Authors:  W Reid Bolus; Alyssa H Hasty
Journal:  J Lipid Res       Date:  2018-06-11       Impact factor: 5.922
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.