OBJECTIVES: Few neurophysiological studies have investigated cerebellar function in patients with essential tremor, even though the cerebellum may contribute to tremor generation. Here, we studied cerebellar function in patients with essential tremor using 2 physiological methods. METHODS: Participants were 20 patients with essential tremor and 30 age-matched healthy volunteers, and the results were compared across the groups. We studied motor cortical inhibition using cerebellar magnetic stimulation and prism adaptation. RESULTS: Both cerebellar inhibition and prism adaptation were affected in patients with essential tremor. The degree of tremor did not correlate with the degree of abnormality in either of the 2 experiments. CONCLUSIONS: The simplest explanation for the present results is that the cerebellum itself, including the Purkinje cells, is involved in essential tremor, which may reflect a primary pathogenic lesion or secondary compensatory physiological phenomenon to an original pathogenic lesion elsewhere.
OBJECTIVES: Few neurophysiological studies have investigated cerebellar function in patients with essential tremor, even though the cerebellum may contribute to tremor generation. Here, we studied cerebellar function in patients with essential tremor using 2 physiological methods. METHODS:Participants were 20 patients with essential tremor and 30 age-matched healthy volunteers, and the results were compared across the groups. We studied motor cortical inhibition using cerebellar magnetic stimulation and prism adaptation. RESULTS: Both cerebellar inhibition and prism adaptation were affected in patients with essential tremor. The degree of tremor did not correlate with the degree of abnormality in either of the 2 experiments. CONCLUSIONS: The simplest explanation for the present results is that the cerebellum itself, including the Purkinje cells, is involved in essential tremor, which may reflect a primary pathogenic lesion or secondary compensatory physiological phenomenon to an original pathogenic lesion elsewhere.
Authors: Laura Bindel; Christoph Mühlberg; Victoria Pfeiffer; Matthias Nitschke; Annekatrin Müller; Mirko Wegscheider; Jost-Julian Rumpf; Kirsten E Zeuner; Jos S Becktepe; Julius Welzel; Miriam Güthe; Joseph Classen; Elinor Tzvi Journal: Cerebellum Date: 2022-09-09 Impact factor: 3.648
Authors: Tess E K Cersonsky; Sarah Kellner; Silvia Chapman; Edward D Huey; Elan D Louis; Stephanie Cosentino Journal: J Int Neuropsychol Soc Date: 2019-10-04 Impact factor: 2.892