Literature DB >> 2706191

Effect of oral activated charcoal on quinine elimination.

D Lockey1, D N Bateman.   

Abstract

The effect of repeated dose oral activated charcoal on quinine elimination has been studied following a therapeutic (600 mg) dose of quinine bisulphate to seven normal volunteers. Activated charcoal lowered quinine half-life from 8.23 +/- 0.57 s.d. h to 4.55 +/- 0.15 s.d. h (P less than 0.001) and increased its oral clearance by 56%. Activated charcoal may have a role in the management of quinine poisoning.

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Year:  1989        PMID： 2706191      PMCID： PMC1379710          DOI： 10.1111/j.1365-2125.1989.tb05340.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  5 in total

1.  QUANTITATIVE DETERMINATION OF QUINIDINE IN PLASMA.

Authors:  G CRAMER; B ISAKSSON
Journal:  Scand J Clin Lab Invest       Date:  1963       Impact factor: 1.713

Review 2.  Use of activated charcoal in acute poisoning.

Authors:  J W Hayden; E G Comstock
Journal:  Clin Toxicol       Date:  1975       Impact factor: 4.467

3.  Pharmacokinetics and clinical toxicity of quinine overdosage: lack of efficacy of techniques intended to enhance elimination.

Authors:  D N Bateman; P G Blain; K W Woodhouse; M D Rawlins; H Dyson; R Heyworth; L F Prescott; A T Proudfoot
Journal:  Q J Med       Date:  1985-02

4.  Gastrointestinal clearance of drugs with activated charcoal.

Authors:  G Levy
Journal:  N Engl J Med       Date:  1982-09-09       Impact factor: 91.245

5.  Complications of quinine poisoning.

Authors:  M E Boland; S M Roper; J A Henry
Journal:  Lancet       Date:  1985-02-16       Impact factor: 79.321
  5 in total
  7 in total

1.  The management of quinine-induced blindness.

Authors:  U Guly; P Driscoll
Journal:  Arch Emerg Med       Date:  1992-09

Review 2.  Pharmacokinetics of quinine, chloroquine and amodiaquine. Clinical implications.

Authors:  S Krishna; N J White
Journal:  Clin Pharmacokinet       Date:  1996-04       Impact factor: 6.447

Review 3.  Treatment of malaria--1990.

Authors:  D M Panisko; J S Keystone
Journal:  Drugs       Date:  1990-02       Impact factor: 9.546

4.  Treatment of quinine overdosage with repeated oral charcoal.

Authors:  L F Prescott; A R Hamilton; R Heyworth
Journal:  Br J Clin Pharmacol       Date:  1989-01       Impact factor: 4.335

5.  Quinine intoxications reported to the Scottish Poisons Information Bureau 1997-2002: a continuing problem.

Authors:  N J Langford; A M Good; W J Laing; D N Bateman
Journal:  Br J Clin Pharmacol       Date:  2003-11       Impact factor: 4.335

6.  Oral activated charcoal prevents experimental cerebral malaria in mice and in a randomized controlled clinical trial in man did not interfere with the pharmacokinetics of parenteral artesunate.

Authors:  J Brian de Souza; Uduak Okomo; Neal D Alexander; Naveed Aziz; Benjamin M J Owens; Harparkash Kaur; Momodou Jasseh; Sant Muangnoicharoen; Percy F Sumariwalla; David C Warhurst; Stephen A Ward; David J Conway; Luis Ulloa; Kevin J Tracey; Brian M J Foxwell; Paul M Kaye; Michael Walther
Journal:  PLoS One       Date:  2010-04-15       Impact factor: 3.240

7.  Novel Therapies for Myocardial Irritability following Extreme Hydroxychloroquine Toxicity.

Authors:  Paul B McBeth; Perseus I Missirlis; Harry Brar; Vinay Dhingra
Journal:  Case Rep Emerg Med       Date:  2015-08-17
  7 in total

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