Literature DB >> 27061598

Synthesis of a doxycycline-[(13) CD3 ] standard.

James E Bupp1, Mary J Tanga1.   

Abstract

A stable isotope labelled mass spectrometry internal standard of the antibiotic doxycycline was prepared to assist in pharmacokinetic analyses. Our approach was to first N-demethylate doxycycline using a non-classical Polonovski reaction and then re-methylate using methyl-[(13) CD3 ] iodide, which gave doxycycline-[(13) CD3 ] with an isotopic purity of 99%.
Copyright © 2016 John Wiley & Sons, Ltd.

Entities:  

Keywords:  MS internal standard; antibiotic; demethylation; doxycycline

Mesh：

Substances：

Year:  2016        PMID： 27061598      PMCID： PMC4892950          DOI： 10.1002/jlcr.3397

Source DB:  PubMed          Journal:  J Labelled Comp Radiopharm        ISSN： 0362-4803            Impact factor:   1.921


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