BACKGROUND: Cerebral amyloid angiopathy (CAA) is increasingly recognized as a cause of cognitive impairment in the elderly, but the cognitive profile in patients with the disease has not been well characterized. OBJECTIVE: To characterize the neuropsychological profile of CAA patients without dementia and to determine the association between cognitive performance in different domains and neuroimaging lesions characteristic of CAA. METHODS: Fifty-eight non-demented CAA patients were compared to 138 cognitively normal subjects using a standard neuropsychological test battery. Total brain volume (TBV), white matter hyperintensities, number of lobar cerebral microbleeds, hippocampal volume, and cortical superficial siderosis in all CAA patients were assessed. The association between these neuroimaging markers and neuropsychological performance in different cognitive domains in the CAA group were analyzed. RESULTS: Patients with CAA had significantly worse performance on all individual neuropsychological domains tested, when compared to the cognitive normal group. The cognitive decline of CAA patients was most noticeable in tests for processing speed with a Z score of -1.92±1.56 (mean±SD), then followed by executive function (-0.93±1.01), episodic memory (-0.87±1.29), semantic fluency (-0.73±1.06), and attention (-0.42±0.98). TBV of the CAA patients was correlated with processing speed (β= 0.335, p = 0.03) and executive function (β= 0.394, p = 0.01). CONCLUSIONS: Non-demented patients with CAA had cognitive deficits in multiple areas. Lower TBV was related to slower processing speed and worse executive function.
BACKGROUND:Cerebral amyloid angiopathy (CAA) is increasingly recognized as a cause of cognitive impairment in the elderly, but the cognitive profile in patients with the disease has not been well characterized. OBJECTIVE: To characterize the neuropsychological profile of CAA patients without dementia and to determine the association between cognitive performance in different domains and neuroimaging lesions characteristic of CAA. METHODS: Fifty-eight non-demented CAA patients were compared to 138 cognitively normal subjects using a standard neuropsychological test battery. Total brain volume (TBV), white matter hyperintensities, number of lobar cerebral microbleeds, hippocampal volume, and cortical superficial siderosis in all CAA patients were assessed. The association between these neuroimaging markers and neuropsychological performance in different cognitive domains in the CAA group were analyzed. RESULTS:Patients with CAA had significantly worse performance on all individual neuropsychological domains tested, when compared to the cognitive normal group. The cognitive decline of CAA patients was most noticeable in tests for processing speed with a Z score of -1.92±1.56 (mean±SD), then followed by executive function (-0.93±1.01), episodic memory (-0.87±1.29), semantic fluency (-0.73±1.06), and attention (-0.42±0.98). TBV of the CAA patients was correlated with processing speed (β= 0.335, p = 0.03) and executive function (β= 0.394, p = 0.01). CONCLUSIONS: Non-demented patients with CAA had cognitive deficits in multiple areas. Lower TBV was related to slower processing speed and worse executive function.
Authors: Andreas Charidimou; Gregoire Boulouis; M Edip Gurol; Cenk Ayata; Brian J Bacskai; Matthew P Frosch; Anand Viswanathan; Steven M Greenberg Journal: Brain Date: 2017-07-01 Impact factor: 13.501
Authors: François De Guio; Marco Duering; Franz Fazekas; Frank-Erik De Leeuw; Steven M Greenberg; Leonardo Pantoni; Agnès Aghetti; Eric E Smith; Joanna Wardlaw; Eric Jouvent Journal: J Cereb Blood Flow Metab Date: 2019-11-20 Impact factor: 6.200
Authors: Gregoire Boulouis; Andreas Charidimou; Michael J Jessel; Li Xiong; Duangnapa Roongpiboonsopit; Panagiotis Fotiadis; Marco Pasi; Alison Ayres; M Emily Merrill; Kristin M Schwab; Jonathan Rosand; M Edip Gurol; Steven M Greenberg; Anand Viswanathan Journal: Neurology Date: 2017-01-27 Impact factor: 9.910
Authors: María Carmona-Iragui; Mircea Balasa; Bessy Benejam; Daniel Alcolea; Susana Fernández; Laura Videla; Isabel Sala; María Belén Sánchez-Saudinós; Estrella Morenas-Rodriguez; Roser Ribosa-Nogué; Ignacio Illán-Gala; Sofía Gonzalez-Ortiz; Jordi Clarimón; Frederick Schmitt; David K Powell; Beatriz Bosch; Albert Lladó; Michael S Rafii; Elizabeth Head; José Luis Molinuevo; Rafael Blesa; Sebastián Videla; Alberto Lleó; Raquel Sánchez-Valle; Juan Fortea Journal: Alzheimers Dement Date: 2017-04-29 Impact factor: 21.566
Authors: Thanakit Pongpitakmetha; Panagiotis Fotiadis; Marco Pasi; Gregoire Boulouis; Li Xiong; Andrew D Warren; Kristin M Schwab; Jonathan Rosand; M Edip Gurol; Steven M Greenberg; Anand Viswanathan; Andreas Charidimou Journal: Neurology Date: 2020-04-13 Impact factor: 9.910
Authors: V Perosa; T Arts; A Assmann; H Mattern; O Speck; J Oltmer; H-J Heinze; E Düzel; S Schreiber; J J M Zwanenburg Journal: AJNR Am J Neuroradiol Date: 2022-03-24 Impact factor: 3.825
Authors: Ibrahim Shaikh; Christian Beaulieu; Myrlene Gee; Cheryl R McCreary; Andrew E Beaudin; Diana Valdés-Cabrera; Eric E Smith; Richard Camicioli Journal: Neuroimage Clin Date: 2022-04-04 Impact factor: 4.891
Authors: Gargi Banerjee; Roxana Carare; Charlotte Cordonnier; Steven M Greenberg; Julie A Schneider; Eric E Smith; Mark van Buchem; Jeroen van der Grond; Marcel M Verbeek; David J Werring Journal: J Neurol Neurosurg Psychiatry Date: 2017-08-26 Impact factor: 10.154