Alexandra Chapuis1, Cécile Chabrot2, Audrey Mirand3, Philippe Poirier4, Céline Nourrisson5. 1. Laboratoire de Parasitologie-Mycologie, Centre de Biologie, CHU Gabriel Montpied, 58, rue Montalembert, F-63003 Clermont-Ferrand, France. 2. Service d'Hématologie clinique et Thérapie cellulaire, CHU Estaing, Clermont-Ferrand, France. 3. Service de Virologie, Centre National de Référence des Enterovirus-Parechovirus, Clermont-Ferrand, France; Université d'Auvergne, EA4843 « Epidémiologie et Pathogénie des Infections à Entérovirus », Faculté de Médecine, Clermont-Ferrand, France. 4. Laboratoire de Parasitologie-Mycologie, Centre de Biologie, CHU Gabriel Montpied, 58, rue Montalembert, F-63003 Clermont-Ferrand, France; Clermont Université, Université Blaise Pascal-Université d'Auvergne-CNRS, UMR 6023 Laboratoire Microorganismes: Génome et Environnement, Clermont-Ferrand, France. 5. Laboratoire de Parasitologie-Mycologie, Centre de Biologie, CHU Gabriel Montpied, 58, rue Montalembert, F-63003 Clermont-Ferrand, France; Clermont Université, Université Blaise Pascal-Université d'Auvergne-CNRS, UMR 6023 Laboratoire Microorganismes: Génome et Environnement, Clermont-Ferrand, France. Electronic address: c_nourrisson@chu-clermontferrand.fr.
Abstract
BACKGROUND: The case of a central nervous system human herpes virus type 6 (HHV-6) and Toxoplasma gondii co-infection after an umbilical cord blood transplantation in a chronic myelomonocytic leukaemia patient is reported. CASE REPORT: A 65-year-old Caucasian man underwent an umbilical cord blood transplantation within the context of chronic myelomonocytic leukaemia. On day 37 post-graft, he presented with a severe headache; PCRs of cerebrospinal fluid and blood were positive for T. gondii and HHV-6. The patient was treated with pyrimethamine and sulfadiazine associated with ganciclovir. CONCLUSION: HHV-6 reactivation can trigger a reactivation of T. gondii. This case suggests that patients who are seropositive for T. gondii and who present with HHV-6 reactivation should be monitored closely for toxoplasmosis.
BACKGROUND: The case of a central nervous system human herpes virus type 6 (HHV-6) and Toxoplasma gondii co-infection after an umbilical cord blood transplantation in a chronic myelomonocytic leukaemiapatient is reported. CASE REPORT: A 65-year-old Caucasian man underwent an umbilical cord blood transplantation within the context of chronic myelomonocytic leukaemia. On day 37 post-graft, he presented with a severe headache; PCRs of cerebrospinal fluid and blood were positive for T. gondii and HHV-6. The patient was treated with pyrimethamine and sulfadiazine associated with ganciclovir. CONCLUSION:HHV-6 reactivation can trigger a reactivation of T. gondii. This case suggests that patients who are seropositive for T. gondii and who present with HHV-6 reactivation should be monitored closely for toxoplasmosis.