OBJECTIVE: Scant clinical data are available on the effects of current treatments for asthma on different subgroups of patients with this disease. We conducted a prospective, noninterventional, multicenter real-life study in adult patients with persistent asthma, and we specifically analyzed the effects of treatment with extrafine beclometasone dipropionate/formoterol (BDP/F) in asthma patients categorized by phenotypes related to small airways (i.e. smoking habits, disease duration, and air trapping). METHODS: Patients received BDP/F as a fixed combination (100/6 μg), administered in 1-2 inhalations twice daily over a period of 12 weeks. Peak expiratory flow (PEF), forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), number of asthma attacks, asthma control, and severity of asthma symptoms were evaluated in the overall population and in different subgroups at three different time points. RESULTS: Overall, 213 patients were enrolled. In the overall population the treatment resulted in a significant increase in the proportion of well controlled patients (from 6.1% to 66.3%; p<0.001), and a reduction of uncontrolled subjects (70.3% versus 10.0%; p<0.001). BDP/F was also associated with a reduction in asthma attacks and an improvement of symptoms. These results were confirmed in specific subgroups of patients identified as small airway phenotypes: smokers, elderly patients, those with long duration of disease and air trapping. CONCLUSIONS: This real-life observational study indicates that extrafine BDP/F in a fixed combination improves asthma control and symptoms in the overall population as well as specific subgroups of patients.
OBJECTIVE: Scant clinical data are available on the effects of current treatments for asthma on different subgroups of patients with this disease. We conducted a prospective, noninterventional, multicenter real-life study in adult patients with persistent asthma, and we specifically analyzed the effects of treatment with extrafinebeclometasone dipropionate/formoterol (BDP/F) in asthma patients categorized by phenotypes related to small airways (i.e. smoking habits, disease duration, and air trapping). METHODS:Patients received BDP/F as a fixed combination (100/6 μg), administered in 1-2 inhalations twice daily over a period of 12 weeks. Peak expiratory flow (PEF), forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), number of asthma attacks, asthma control, and severity of asthma symptoms were evaluated in the overall population and in different subgroups at three different time points. RESULTS: Overall, 213 patients were enrolled. In the overall population the treatment resulted in a significant increase in the proportion of well controlled patients (from 6.1% to 66.3%; p<0.001), and a reduction of uncontrolled subjects (70.3% versus 10.0%; p<0.001). BDP/F was also associated with a reduction in asthma attacks and an improvement of symptoms. These results were confirmed in specific subgroups of patients identified as small airway phenotypes: smokers, elderly patients, those with long duration of disease and air trapping. CONCLUSIONS: This real-life observational study indicates that extrafineBDP/F in a fixed combination improves asthma control and symptoms in the overall population as well as specific subgroups of patients.
Authors: M Contoli; J Bousquet; L M Fabbri; H Magnussen; K F Rabe; N M Siafakas; Q Hamid; M Kraft Journal: Allergy Date: 2009-11-11 Impact factor: 13.146
Authors: T A Popov; D Petrova; T Z Kralimarkova; Y Ivanov; T Popova; M Peneva; T Odzhakova; Y Ilieva; P Yakovliev; T Lazarova; O Georgiev; V Hodzhev; E Hodzheva; M T Staevska; V D Dimitrov Journal: Pulm Pharmacol Ther Date: 2013-06-14 Impact factor: 3.410
Authors: Pascal Chanez; Sally E Wenzel; Gary P Anderson; Josep M Anto; Elisabeth H Bel; Louis-Philippe Boulet; Christopher E Brightling; William W Busse; Mario Castro; Babro Dahlen; Sven Erik Dahlen; Leo M Fabbri; Stephen T Holgate; Marc Humbert; Mina Gaga; Guy F Joos; Bruce Levy; Klaus F Rabe; Peter J Sterk; Susan J Wilson; Isabelle Vachier Journal: J Allergy Clin Immunol Date: 2007-04-09 Impact factor: 10.793
Authors: Marcello Cottini; Carlo Lombardi; Giovanni Passalacqua; Diego Bagnasco; Alvise Berti; Pasquale Comberiati; Gianluca Imeri; Massimo Landi; Enrico Heffler Journal: Front Med (Lausanne) Date: 2022-05-23