Literature DB >> 27060069

Alopecia areata and narcolepsy: a tale of obscure autoimmunity.

Gaurav Nigam1, Charu Pathak2, Muhammad Riaz1.   

Abstract

Alopecia areata is an autoimmune dermatological disorder characterised by loss of hair in one or more discrete patches over the scalp. It has been linked to multiple disorders having an autoimmune origin. Like many autoimmune disorders it tends to be more common in females. To date, only five cases have been reported where alopecia has been associated with narcolepsy. Male gender is less commonly affected by alopecia areata. No case of alopecia areata in males has been associated with narcolepsy to the best of our knowledge. The current case represents the first ever-reported case of alopecia areata in a male patient with narcolepsy type 1. This coexistence is most likely the manifestation of a common underlying pathoimmunological mechanism that has not been completely understood, rather than a random association. 2016 BMJ Publishing Group Ltd.

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Year:  2016        PMID: 27060069      PMCID: PMC4840720          DOI: 10.1136/bcr-2015-211523

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  7 in total

Review 1.  International classification of sleep disorders-third edition: highlights and modifications.

Authors:  Michael J Sateia
Journal:  Chest       Date:  2014-11       Impact factor: 9.410

2.  Collapse and restoration of MHC class-I-dependent immune privilege: exploiting the human hair follicle as a model.

Authors:  Taisuke Ito; Natsuho Ito; Albrecht Bettermann; Yoshiki Tokura; Masahiro Takigawa; Ralf Paus
Journal:  Am J Pathol       Date:  2004-02       Impact factor: 4.307

3.  A potential association between alopecia areata and narcolepsy.

Authors:  Lloyd E King; Allyson W Eastham; Natalie M Curcio; Adriana N Schmidt
Journal:  Arch Dermatol       Date:  2010-06

4.  Comorbidity profiles among patients with alopecia areata: the importance of onset age, a nationwide population-based study.

Authors:  Szu-Ying Chu; Yi-Ju Chen; Wei-Cheng Tseng; Ming-Wei Lin; Tzeng-Ji Chen; Chian-Yaw Hwang; Chih-Chiang Chen; Ding-Dar Lee; Yun-Ting Chang; Wen-Jen Wang; Han-Nan Liu
Journal:  J Am Acad Dermatol       Date:  2011-05-25       Impact factor: 11.527

5.  Anti-Tribbles homolog 2 (TRIB2) autoantibodies in narcolepsy are associated with recent onset of cataplexy.

Authors:  Minae Kawashima; Ling Lin; Susumu Tanaka; Poul Jennum; Stine Knudsen; Sona Nevsimalova; Giuseppe Plazzi; Emmanuel Mignot
Journal:  Sleep       Date:  2010-07       Impact factor: 5.849

6.  [Narcolepsy and alopecia areata: a new association?].

Authors:  L Domínguez Ortega
Journal:  An Med Interna       Date:  1992-05

7.  Narcolepsy is strongly associated with the T-cell receptor alpha locus.

Authors:  Joachim Hallmayer; Juliette Faraco; Ling Lin; Stephanie Hesselson; Juliane Winkelmann; Minae Kawashima; Geert Mayer; Giuseppe Plazzi; Sona Nevsimalova; Patrice Bourgin; Seung-Chul Hong; Sheng Seung-Chul Hong; Yutaka Honda; Makoto Honda; Birgit Högl; William T Longstreth; Jacques Montplaisir; David Kemlink; Mali Einen; Justin Chen; Stacy L Musone; Matthew Akana; Taku Miyagawa; Jubao Duan; Alex Desautels; Christine Erhardt; Per Egil Hesla; Francesca Poli; Birgit Frauscher; Jong-Hyun Jeong; Sung-Pil Lee; Thanh G N Ton; Mark Kvale; Libor Kolesar; Marie Dobrovolná; Gerald T Nepom; Dan Salomon; H-Erich Wichmann; Guy A Rouleau; Christian Gieger; Douglas F Levinson; Pablo V Gejman; Thomas Meitinger; Terry Young; Paul Peppard; Katsushi Tokunaga; Pui-Yan Kwok; Neil Risch; Emmanuel Mignot
Journal:  Nat Genet       Date:  2009-05-03       Impact factor: 38.330

  7 in total
  1 in total

1.  Long-Term Outcome of a Series of Patients With Narcolepsy Type 1 and Comorbidity With Immunopathological and Autoimmune Diseases.

Authors:  Francisco J Martinez-Orozco; Miguel Fernandez-Arquero; Jose L Vicario; Laura Lillo-Triguero; Elena Ameyugo; Rosa Peraita-Adrados
Journal:  J Clin Med Res       Date:  2022-08-27
  1 in total

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