Literature DB >> 27060051

Multiple antigens of Yersinia pestis delivered by live recombinant attenuated Salmonella vaccine strains elicit protective immunity against plague.

Shilpa Sanapala1, Hannah Rahav1, Hetal Patel1, Wei Sun2, Roy Curtiss3.   

Abstract

Based on our improved novel Salmonella vaccine delivery platform, we optimized the recombinant attenuated Salmonella typhimurium vaccine (RASV) χ12094 to deliver multiple Yersinia pestis antigens. These included LcrV196 (amino acids, 131-326), Psn encoded on pYA5383 and F1 encoded in the chromosome, their synthesis did not cause adverse effects on bacterial growth. Oral immunization with χ12094(pYA5383) simultaneously stimulated high antibody titers to LcrV, Psn and F1 in mice and presented complete protection against both subcutaneous (s.c.) and intranasal (i.n.) challenges with high lethal doses of Y. pestis CO92. Moreover, no deaths or other disease symptoms were observed in SCID mice orally immunized with χ12094(pYA5383) over a 60-day period. Therefore, the trivalent S. typhimurium-based live vaccine shows promise for a next-generation plague vaccine.
Copyright © 2016 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  F1 and Psn; LcrV; Plague; Recombinant Salmonella vaccine; Trivalent vaccine

Mesh：

Substances：

Year:  2016        PMID： 27060051      PMCID： PMC5484397          DOI： 10.1016/j.vaccine.2016.03.094

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  46 in total

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Review 2.  New technologies in developing recombinant attenuated Salmonella vaccine vectors.

Authors:  Shifeng Wang; Qingke Kong; Roy Curtiss
Journal:  Microb Pathog       Date:  2012-11-08       Impact factor: 3.738

3.  Prevention of pneumonic plague in mice, rats, guinea pigs and non-human primates with clinical grade rV10, rV10-2 or F1-V vaccines.

Authors:  Lauriane E Quenee; Nancy A Ciletti; Derek Elli; Timothy M Hermanas; Olaf Schneewind
Journal:  Vaccine       Date:  2011-07-16       Impact factor: 3.641

4.  Evaluation of protective potential of Yersinia pestis outer membrane protein antigens as possible candidates for a new-generation recombinant plague vaccine.

Authors:  Tatiana E Erova; Jason A Rosenzweig; Jian Sha; Giovanni Suarez; Johanna C Sierra; Michelle L Kirtley; Christina J van Lier; Maxim V Telepnev; Vladimir L Motin; Ashok K Chopra
Journal:  Clin Vaccine Immunol       Date:  2012-12-12

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Journal:  Arch Pathol Lab Med       Date:  1996-02       Impact factor: 5.534

6.  Plague in Guinea pigs and its prevention by subunit vaccines.

Authors:  Lauriane E Quenee; Nancy Ciletti; Bryan Berube; Thomas Krausz; Derek Elli; Timothy Hermanas; Olaf Schneewind
Journal:  Am J Pathol       Date:  2011-03-04       Impact factor: 4.307

7.  Evaluation of the humoral immune response in mice orally vaccinated with live recombinant attenuated Salmonella enterica delivering a secreted form of Yersinia pestis PsaA.

Authors:  Ascención Torres-Escobar; María Dolores Juárez-Rodríguez; Christine G Branger; Roy Curtiss
Journal:  Vaccine       Date:  2010-07-13       Impact factor: 3.641

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Journal:  Infect Immun       Date:  1994-10       Impact factor: 3.441

9.  Evaluation of new generation Salmonella enterica serovar Typhimurium vaccines with regulated delayed attenuation to induce immune responses against PspA.

Authors:  Yuhua Li; Shifeng Wang; Giorgio Scarpellini; Bronwyn Gunn; Wei Xin; Soo-Young Wanda; Kenneth L Roland; Roy Curtiss
Journal:  Proc Natl Acad Sci U S A       Date:  2008-12-29       Impact factor: 11.205

Review 10.  Current challenges in the development of vaccines for pneumonic plague.

Authors:  Stephen T Smiley
Journal:  Expert Rev Vaccines       Date:  2008-03       Impact factor: 5.217
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  7 in total

1.  Oral vaccination with live attenuated Yersinia pseudotuberculosis strains delivering a FliC180-LcrV fusion antigen confers protection against pulmonary Y. Pestis infection.

Authors:  Amit K Singh; Xiuran Wang; Wei Sun
Journal:  Vaccine       Date:  2020-04-08       Impact factor: 3.641

2.  Immunogenicity and protection efficacy of enhanced fitness recombinant Salmonella Typhi monovalent and bivalent vaccine strains against acute toxoplasmosis.

Authors:  Fei-Kean Loh; Sheila Nathan; Sek-Chuen Chow; Chee-Mun Fang
Journal:  Pathog Glob Health       Date:  2021-02-01       Impact factor: 2.894

3.  Crystal structure of Yersinia pestis virulence factor YfeA reveals two polyspecific metal-binding sites.

Authors:  Christopher D Radka; Lawrence J DeLucas; Landon S Wilson; Matthew B Lawrenz; Robert D Perry; Stephen G Aller
Journal:  Acta Crystallogr D Struct Biol       Date:  2017-06-30       Impact factor: 7.652

4.  Comparative evaluation of Salmonella Typhimurium vaccines derived from UK-1 and 14028S: Importance of inherent virulence.

Authors:  Shilpa Sanapala; Leandra Mosca; Shifeng Wang; Roy Curtiss
Journal:  PLoS One       Date:  2018-09-07       Impact factor: 3.240

Review 5.  Plague vaccine: recent progress and prospects.

Authors:  Wei Sun; Amit K Singh
Journal:  NPJ Vaccines       Date:  2019-02-18       Impact factor: 9.399

6.  Yersinia pestis Antigen F1 but Not LcrV Induced Humoral and Cellular Immune Responses in Humans Immunized with Live Plague Vaccine-Comparison of Immunoinformatic and Immunological Approaches.

Authors:  Valentina A Feodorova; Anna M Lyapina; Maria A Khizhnyakova; Sergey S Zaitsev; Yury V Saltykov; Vladimir L Motin
Journal:  Vaccines (Basel)       Date:  2020-11-19

7.  Induction of Protective Antiplague Immune Responses by Self-Adjuvanting Bionanoparticles Derived from Engineered Yersinia pestis.

Authors:  Xiuran Wang; Amit K Singh; Xiangmin Zhang; Wei Sun
Journal:  Infect Immun       Date:  2020-04-20       Impact factor: 3.441
  7 in total

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