Literature DB >> 2706003

Regulation of 5-methyltetrahydrofolate synthesis.

M Lumb1, T Bottiglieri, R Deacon, J Perry, I Chanarin.   

Abstract

After an intraperitoneal injection of 100 mumol of methionine to rats, there is rapid oxidation of the methyl group of hepatic 5-methyltetrahydrofolate to formate and CO2. Recovery of the methylfolate level starts 2.5 h after the methionine injection, when the hepatic methionine level and the S-adenosylmethionine/S-adenosylhomocysteine ratio have returned to baseline values. S-Adenosylmethionine concentration is still elevated at this time.

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Year:  1989        PMID： 2706003      PMCID： PMC1138405          DOI： 10.1042/bj2580611

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  7 in total

1.  5-Methyltetrahydrofolate aromatic alkylamine N-methyltransferase: an artefact of 5,10-methylenetetrahydrofolate reductase activity.

Authors:  R T Taylor; M L Hanna
Journal:  Life Sci       Date:  1975-07-01       Impact factor: 5.037

2.  Folate-dependent 1-carbon transfer to biogenic amines mediated by methylenetetrahydrofolate reductase.

Authors:  A G Pearson; A J Turner
Journal:  Nature       Date:  1975-11-13       Impact factor: 49.962

3.  Examination of the role of methylenetetrahydrofolate reductase in incorporation of methyltetrahydrofolate into cellular metabolism.

Authors:  J M Green; D P Ballou; R G Matthews
Journal:  FASEB J       Date:  1988-01       Impact factor: 5.191

4.  The effect of storage on rat tissues and human plasma amino acid levels determined by HPLC.

Authors:  T Bottiglieri
Journal:  Biomed Chromatogr       Date:  1987       Impact factor: 1.902

5.  Mammalian methylenetetrahydrofolate reductase. Partial purification, properties, and inhibition by S-adenosylmethionine.

Authors:  C Kutzbach; E L Stokstad
Journal:  Biochim Biophys Acta       Date:  1971-12-15

6.  In vivo oxidation of the methyl group of hepatic 5-methyltetrahydrofolate.

Authors:  M Lumb; I Chanarin; R Deacon; J Perry
Journal:  J Clin Pathol       Date:  1988-11       Impact factor: 3.411

7.  Folate pentaglutamate and folate hexaglutamate mediated one-carbon metabolism.

Authors:  T Brody; J E Watson; E L Stokstad
Journal:  Biochemistry       Date:  1982-01-19       Impact factor: 3.162
  7 in total
  2 in total

Review 1.  Cobalamin and folate: recent developments.

Authors:  I Chanarin; R Deacon; M Lumb; J Perry
Journal:  J Clin Pathol       Date:  1992-04       Impact factor: 3.411

2.  A weak link in metabolism: the metabolic capacity for glycine biosynthesis does not satisfy the need for collagen synthesis.

Authors:  Enrique Meléndez-Hevia; Patricia De Paz-Lugo; Athel Cornish-Bowden; María Luz Cárdenas
Journal:  J Biosci       Date:  2009-12       Impact factor: 1.826
  2 in total

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