Maxime Donadieu1,2,3, Yann Le Fur4,5, Sylviane Confort-Gouny4,5, Arnaud Le Troter4,5, Maxime Guye4,5, Jean-Philippe Ranjeva4,5. 1. Faculté de Médecine de la Timone, Centre de Résonance Magnétique Biologique et Médicale (CRMBM, UMR CNRS-AMU 7339), Medical School of Marseille, Aix Marseille Université, 27, Boulevard Jean Moulin, 13385, Marseille Cedex 05, France. maxime.donadieu@etu.univ-amu.fr. 2. AP-HM, CHU Timone, Pôle d'Imagerie, CEMEREM, 13385, Marseille, France. maxime.donadieu@etu.univ-amu.fr. 3. Siemens Healthcare, St-Denis, France. maxime.donadieu@etu.univ-amu.fr. 4. Faculté de Médecine de la Timone, Centre de Résonance Magnétique Biologique et Médicale (CRMBM, UMR CNRS-AMU 7339), Medical School of Marseille, Aix Marseille Université, 27, Boulevard Jean Moulin, 13385, Marseille Cedex 05, France. 5. AP-HM, CHU Timone, Pôle d'Imagerie, CEMEREM, 13385, Marseille, France.
Abstract
OBJECTIVE: To demonstrate that high resolution (1)H semi-LASER MRSI acquired at 7 T permits discrimination of metabolic patterns of different thalamic nuclei. MATERIALS AND METHODS: Thirteen right-handed healthy volunteers were explored at 7 T using a high-resolution 2D-semi-LASER (1)H-MRSI sequence to determine the relative levels of N-Acetyl Aspartate (NAA), choline (Cho) and creatine-phosphocreatine (Cr) in eight VOIs (volume <0.3 ml) centered on four different thalamic nuclei located on the Oxford thalamic connectivity atlas. Post-processing was done using the CSIAPO software. Chemical shift displacement of metabolites was evaluated on a phantom and correction factors were applied to in vivo data. RESULTS: The global assessment (ANOVA p < 0.05) of the neurochemical profiles (NAA, Cho and Cr levels) with thalamic nuclei and hemispheres as factors showed a significant global effect (F = 11.98, p < 0.0001), with significant effect of nucleus type (p < 0.0001) and hemisphere (p < 0.0001). Post hoc analyses showed differences in neurochemical profiles between the left and the right hemisphere (p < 0.05), and differences in neurochemical profiles between nuclei within each hemisphere (p < 0.05). CONCLUSION: For the first time, using high resolution 2D-PRESS semi-LASER (1)H-MRSI acquired at 7 T, we demonstrated that the neurochemical profiles were different between thalamic nuclei, and that these profiles were dependent on the brain hemisphere.
OBJECTIVE: To demonstrate that high resolution (1)H semi-LASER MRSI acquired at 7 T permits discrimination of metabolic patterns of different thalamic nuclei. MATERIALS AND METHODS: Thirteen right-handed healthy volunteers were explored at 7 T using a high-resolution 2D-semi-LASER (1)H-MRSI sequence to determine the relative levels of N-Acetyl Aspartate (NAA), choline (Cho) and creatine-phosphocreatine (Cr) in eight VOIs (volume <0.3 ml) centered on four different thalamic nuclei located on the Oxford thalamic connectivity atlas. Post-processing was done using the CSIAPO software. Chemical shift displacement of metabolites was evaluated on a phantom and correction factors were applied to in vivo data. RESULTS: The global assessment (ANOVA p < 0.05) of the neurochemical profiles (NAA, Cho and Cr levels) with thalamic nuclei and hemispheres as factors showed a significant global effect (F = 11.98, p < 0.0001), with significant effect of nucleus type (p < 0.0001) and hemisphere (p < 0.0001). Post hoc analyses showed differences in neurochemical profiles between the left and the right hemisphere (p < 0.05), and differences in neurochemical profiles between nuclei within each hemisphere (p < 0.05). CONCLUSION: For the first time, using high resolution 2D-PRESS semi-LASER (1)H-MRSI acquired at 7 T, we demonstrated that the neurochemical profiles were different between thalamic nuclei, and that these profiles were dependent on the brain hemisphere.
Entities:
Keywords:
1H-MRSI; Connectivity atlas; Neurochemical profiles; Thalamic nuclei; Ultra high field
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