| Literature DB >> 27059883 |
Alan J Burns1, Allan M Goldstein2, Donald F Newgreen3, Lincon Stamp4, Karl-Herbert Schäfer5, Marco Metzger6, Ryo Hotta2, Heather M Young4, Peter W Andrews7, Nikhil Thapar8, Jaime Belkind-Gerson9, Nadege Bondurand10, Joel C Bornstein11, Wood Yee Chan12, Kathryn Cheah13, Michael D Gershon14, Robert O Heuckeroth15, Robert M W Hofstra16, Lothar Just17, Raj P Kapur18, Sebastian K King19, Conor J McCann8, Nandor Nagy20, Elly Ngan21, Florian Obermayr22, Vassilis Pachnis23, Pankaj J Pasricha24, Mai Har Sham25, Paul Tam21, Pieter Vanden Berghe26.
Abstract
Over the last 20 years, there has been increasing focus on the development of novel stem cell based therapies for the treatment of disorders and diseases affecting the enteric nervous system (ENS) of the gastrointestinal tract (so-called enteric neuropathies). Here, the idea is that ENS progenitor/stem cells could be transplanted into the gut wall to replace the damaged or absent neurons and glia of the ENS. This White Paper sets out experts' views on the commonly used methods and approaches to identify, isolate, purify, expand and optimize ENS stem cells, transplant them into the bowel, and assess transplant success, including restoration of gut function. We also highlight obstacles that must be overcome in order to progress from successful preclinical studies in animal models to ENS stem cell therapies in the clinic.Entities:
Keywords: Cell replacement therapy; Enteric nervous system; Enteric neuropathies; Hirschsprung disease; Stem cells
Mesh：
Year: 2016 PMID： 27059883 PMCID： PMC5026875 DOI： 10.1016/j.ydbio.2016.04.001
Source DB: PubMed Journal: Dev Biol ISSN： 0012-1606 Impact factor: 3.582