Literature DB >> 27058353

Increasing HIV-1 pretreatment drug resistance among antiretroviral-naïve adults initiating treatment between 2006 and 2014 in Nairobi, Kenya.

Michael H Chung1, Rachel Silverman, Ingrid A Beck, Nelly Yatich, Sandra Dross, Jennifer McKernan-Mullin, Stephen Bii, Kenneth Tapia, Joshua Stern, Bhavna Chohan, Samah R Sakr, James N Kiarie, Lisa M Frenkel.   

Abstract

Antiretroviral-naïve adults initiating antiretroviral therapy in Nairobi, Kenya were tested for HIV-1 drug resistance at codons K103N, Y181C, G190A, M184V, and K65R using an oligonucleotide ligation assay. Prevalence of pretreatment drug resistance increased from 3.89% in 2006 to 10.93% in 2014 (P < 0.001), and 95% of those with resistance had at least one nonnucleoside reverse transcriptase inhibitor mutation. Resistance to tenofovir (K65R) was found in 2014 but not in 2006.

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Year:  2016        PMID： 27058353      PMCID： PMC4889515          DOI： 10.1097/QAD.0000000000001110

Source DB:  PubMed          Journal:  AIDS        ISSN： 0269-9370            Impact factor:   4.177


  11 in total

1.  Oligonucleotide ligation assay detects HIV drug resistance associated with virologic failure among antiretroviral-naive adults in Kenya.

Authors:  Michael H Chung; Ingrid A Beck; Sandra Dross; Kenneth Tapia; James N Kiarie; Barbra A Richardson; Julie Overbaugh; Samah R Sakr; Grace C John-Stewart; Lisa M Frenkel
Journal:  J Acquir Immune Defic Syndr       Date:  2014-11-01       Impact factor: 3.731

2.  Nevirapine resistance by timing of HIV type 1 infection in infants treated with single-dose nevirapine.

Authors:  Mark A Micek; Ana Judith Blanco; Ingrid A Beck; Sandra Dross; Laurinda Matunha; Pablo Montoya; Kristy Seidel; Soren Gantt; Eduardo Matediane; Lilia Jamisse; Stephen Gloyd; Lisa M Frenkel
Journal:  Clin Infect Dis       Date:  2010-05-15       Impact factor: 9.079

3.  Scale-up of antiretroviral treatment in sub-Saharan Africa is accompanied by increasing HIV-1 drug resistance mutations in drug-naive patients.

Authors:  Avelin F Aghokeng; Charles Kouanfack; Christian Laurent; Eugenie Ebong; Arrah Atem-Tambe; Christelle Butel; Celine Montavon; Eitel Mpoudi-Ngole; Eric Delaporte; Martine Peeters
Journal:  AIDS       Date:  2011-11-13       Impact factor: 4.177

4.  HIV-1 drug resistance in antiretroviral-naive individuals in sub-Saharan Africa after rollout of antiretroviral therapy: a multicentre observational study.

Authors:  Raph L Hamers; Carole L Wallis; Cissy Kityo; Margaret Siwale; Kishor Mandaliya; Francesca Conradie; Mariette E Botes; Maureen Wellington; Akin Osibogun; Kim C E Sigaloff; Immaculate Nankya; Rob Schuurman; Ferdinand W Wit; Wendy S Stevens; Michèle van Vugt; Tobias F Rinke de Wit
Journal:  Lancet Infect Dis       Date:  2011-07-27       Impact factor: 25.071

5.  Comparing clinic retention between residents and nonresidents of Kibera, Kenya.

Authors:  Michael H Chung; Pamela Kohler; Mena Attwa; Joan Thiga; Grace C John-Stewart
Journal:  J Acquir Immune Defic Syndr       Date:  2010-03       Impact factor: 3.731

6.  Impact of prior HAART use on clinical outcomes in a large Kenyan HIV treatment program.

Authors:  Michael H Chung; Alison L Drake; Barbra A Richardson; Ashok Reddy; Joan Thiga; Samah R Sakr; James N Kiarie; Paul Yowakim; Grace C John-Stewart
Journal:  Curr HIV Res       Date:  2009-07       Impact factor: 1.581

7.  Low prevalence of transmitted HIV type 1 drug resistance among antiretroviral-naive adults in a rural HIV clinic in Kenya.

Authors:  Amin S Hassan; Shalton M Mwaringa; Clare A Obonyo; Helen M Nabwera; Eduard J Sanders; Tobias F Rinke de Wit; Patricia A Cane; James A Berkley
Journal:  AIDS Res Hum Retroviruses       Date:  2012-09-11       Impact factor: 2.205

8.  Persistence of transmitted drug resistance among subjects with primary human immunodeficiency virus infection.

Authors:  Susan J Little; Simon D W Frost; Joseph K Wong; Davey M Smith; Sergei L Kosakovsky Pond; Caroline C Ignacio; Neil T Parkin; Christos J Petropoulos; Douglas D Richman
Journal:  J Virol       Date:  2008-03-19       Impact factor: 5.103

9.  Comparison of oligonucleotide ligation assay and consensus sequencing for detection of drug-resistant mutants of human immunodeficiency virus type 1 in peripheral blood mononuclear cells and plasma.

Authors:  Giovanina M Ellis; Madhumita Mahalanabis; Ingrid A Beck; Gregory Pepper; Amy Wright; Shannon Hamilton; Sarah Holte; Willscott E Naugler; Diane M Pawluk; Chung-Chen Li; Lisa M Frenkel
Journal:  J Clin Microbiol       Date:  2004-08       Impact factor: 5.948

10.  Global trends in antiretroviral resistance in treatment-naive individuals with HIV after rollout of antiretroviral treatment in resource-limited settings: a global collaborative study and meta-regression analysis.

Authors:  Ravindra K Gupta; Michael R Jordan; Binta J Sultan; Andrew Hill; Daniel H J Davis; John Gregson; Anthony W Sawyer; Raph L Hamers; Nicaise Ndembi; Deenan Pillay; Silvia Bertagnolio
Journal:  Lancet       Date:  2012-07-23       Impact factor: 79.321
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  6 in total

1.  Minority and majority pretreatment HIV-1 drug resistance associated with failure of first-line nonnucleoside reverse-transcriptase inhibitor antiretroviral therapy in Kenyan women.

Authors:  Ross S Milne; Rachel A Silverman; Ingrid A Beck; Jennifer Mckernan-Mullin; Wenjie Deng; Thomas R Sibley; Sandra Dross; James N Kiarie; Samah R Sakr; Robert W Coombs; Michael H Chung; Lisa M Frenkel
Journal:  AIDS       Date:  2019-05-01       Impact factor: 4.177

2.  Prevalence of Pre-antiretroviral-Treatment Drug Resistance by Gender, Age, and Other Factors in HIV-Infected Individuals Initiating Therapy in Kenya, 2013-2014.

Authors:  Rachel A Silverman; Ingrid A Beck; Catherine Kiptinness; Molly Levine; Ross Milne; Christine J McGrath; Steve Bii; Barbra A Richardson; Grace John-Stewart; Bhavna Chohan; Samah R Sakr; James N Kiarie; Lisa M Frenkel; Michael H Chung
Journal:  J Infect Dis       Date:  2017-12-19       Impact factor: 5.226

3.  An analysis of drug resistance among people living with HIV/AIDS in Shanghai, China.

Authors:  Fengdi Zhang; Li Liu; Meiyan Sun; Jianjun Sun; Hongzhou Lu
Journal:  PLoS One       Date:  2017-02-10       Impact factor: 3.240

4.  HIV-1 subtype diversity, transmission networks and transmitted drug resistance amongst acute and early infected MSM populations from Coastal Kenya.

Authors:  Amin S Hassan; Joakim Esbjörnsson; Elizabeth Wahome; Alexander Thiong'o; George N Makau; Mathew A Price; Eduard J Sanders
Journal:  PLoS One       Date:  2018-12-18       Impact factor: 3.240

5.  Prevalence of pretreatment HIV drug resistance in West African and Southeast Asian countries.

Authors:  Nicole Ngo-Giang-Huong; Thu H K Huynh; Anoumou Y Dagnra; Thomas-d'Aquin Toni; Almoustapha I Maiga; Dramane Kania; Sabrina Eymard-Duvernay; Martine Peeters; Cathia Soulie; Gilles Peytavin; Claire Rekacewicz; Marie-Laure Chaix; Avelin F Aghokeng
Journal:  J Antimicrob Chemother       Date:  2019-02-01       Impact factor: 5.790

6.  Predictors of mortality within the first year of initiating antiretroviral therapy in urban and rural Kenya: A prospective cohort study.

Authors:  Rachel A Silverman; Grace C John-Stewart; Ingrid A Beck; Ross Milne; Catherine Kiptinness; Christine J McGrath; Barbra A Richardson; Bhavna Chohan; Samah R Sakr; Lisa M Frenkel; Michael H Chung
Journal:  PLoS One       Date:  2019-10-04       Impact factor: 3.240
  6 in total

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