| Literature DB >> 27058154 |
Yuval Ramot1, Moran Haim-Zada2, Abraham J Domb2, Abraham Nyska3.
Abstract
PLA and its copolymers are commonly used for a wide variety of applications. While they are considered to be biocompatible, side effects resulting from their implantation have been reported. The implantation of biomaterials always results in a foreign body reaction. Such a reaction has also been reported following PLA and its copolymers. This article reviews the process of inflammatory reaction that is to be expected following implantation of PLA, and it highlights specific cases in which the inflammatory reaction can result in safety concerns. The authors also review selected cases from different medical fields to demonstrate possible clinical side effects resulting from its use.Entities:
Keywords: Biocompatibility; Degradable materials; PLA; PLGL; Polymers; Toxicity
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Year: 2016 PMID： 27058154 DOI： 10.1016/j.addr.2016.03.012
Source DB: PubMed Journal: Adv Drug Deliv Rev ISSN： 0169-409X Impact factor: 15.470