Literature DB >> 27057466

MAF drives CD8+ T-cell exhaustion.

Grégory Verdeil1.   

Abstract

The molecular regulation of tumor induced T-cell exhaustion remains poorly characterized. Recently, we compared the transcriptome of "exhausted" CD8+ T cells infiltrating melanomas to those of naive and acutely stimulated CD8+ T cells. We demonstrated that MAF is over-expressed and plays a key role in driving the transcriptional program of T-cell exhaustion.

Entities:  

Keywords:  CD8+ T cell; exhaustion; maf; melanoma

Year:  2015        PMID： 27057466      PMCID： PMC4801447          DOI： 10.1080/2162402X.2015.1082707

Source DB:  PubMed          Journal:  Oncoimmunology        ISSN： 2162-4011            Impact factor:   8.110


  8 in total

1.  Transcription factor c-Maf mediates the TGF-β-dependent suppression of IL-22 production in T(H)17 cells.

Authors:  Sascha Rutz; Rajkumar Noubade; Céline Eidenschenk; Naruhisa Ota; Wenwen Zeng; Yan Zheng; Jason Hackney; Jiabing Ding; Harinder Singh; Wenjun Ouyang
Journal:  Nat Immunol       Date:  2011-10-16       Impact factor: 25.606

2.  Bcl6 and Maf cooperate to instruct human follicular helper CD4 T cell differentiation.

Authors:  Mark A Kroenke; Danelle Eto; Michela Locci; Michael Cho; Terence Davidson; Elias K Haddad; Shane Crotty
Journal:  J Immunol       Date:  2012-03-16       Impact factor: 5.422

Review 3.  T cell exhaustion.

Authors:  E John Wherry
Journal:  Nat Immunol       Date:  2011-06       Impact factor: 25.606

4.  Molecular profiling of CD8 T cells in autochthonous melanoma identifies Maf as driver of exhaustion.

Authors:  Marilyn Giordano; Coralie Henin; Julien Maurizio; Claire Imbratta; Pierre Bourdely; Michel Buferne; Lukas Baitsch; Laurent Vanhille; Michael H Sieweke; Daniel E Speiser; Nathalie Auphan-Anezin; Anne-Marie Schmitt-Verhulst; Grégory Verdeil
Journal:  EMBO J       Date:  2015-07-02       Impact factor: 11.598

Review 5.  From T cell "exhaustion" to anti-cancer immunity.

Authors:  Grégory Verdeil; Silvia A Fuertes Marraco; Timothy Murray; Daniel E Speiser
Journal:  Biochim Biophys Acta       Date:  2015-06-27

6.  Tumor-initiated inflammation overrides protective adaptive immunity in an induced melanoma model in mice.

Authors:  Saïdi M Soudja; Maria Wehbe; Amandine Mas; Lionel Chasson; Céline Powis de Tenbossche; Ivo Huijbers; Benoît Van den Eynde; Anne-Marie Schmitt-Verhulst
Journal:  Cancer Res       Date:  2010-04-20       Impact factor: 12.701

7.  c-Maf regulates IL-10 expression during Th17 polarization.

Authors:  Jiangnan Xu; Yu Yang; Guixing Qiu; Girdhari Lal; Zhihong Wu; David E Levy; Jordi C Ochando; Jonathan S Bromberg; Yaozhong Ding
Journal:  J Immunol       Date:  2009-05-15       Impact factor: 5.422

8.  c-maf promotes T helper cell type 2 (Th2) and attenuates Th1 differentiation by both interleukin 4-dependent and -independent mechanisms.

Authors:  I C Ho; D Lo; L H Glimcher
Journal:  J Exp Med       Date:  1998-11-16       Impact factor: 14.307
  8 in total
  1 in total

Review 1.  Receptor signaling, transcriptional, and metabolic regulation of T cell exhaustion.

Authors:  Mumtaz Y Balkhi
Journal:  Oncoimmunology       Date:  2020-04-14       Impact factor: 8.110
  1 in total

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