Literature DB >> 27057456

Improvement of immunogenic chemotherapy by STAT3 inhibition.

Heng Yang1, Takahiro Yamazaki2, Federico Pietrocola3, Heng Zhou3, Laurence Zitvogel4, Yuting Ma1, Guido Kroemer5.   

Abstract

The inhibition of STAT3 may exert cell-autonomous cytotoxic and cytostatic effects, yet may also stimulate anticancer immunosurveillance through the neutralization of immunosuppressive circuitries. In addition, STAT3 inhibition in cancer cells may stimulate the type 1 interferon response elicited by anthracyclines. This pathway results in an enhanced chemotherapy-associated anticancer immune response with improved therapeutic efficacy. Hence, combination therapies that include immunogenic cell death (ICD) inducers and STAT3 inhibitors can be envisaged.

Entities:  

Year:  2015        PMID： 27057456      PMCID： PMC4801443          DOI： 10.1080/2162402X.2015.1078061

Source DB:  PubMed          Journal:  Oncoimmunology        ISSN： 2162-4011            Impact factor:   8.110


  10 in total

1.  Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy.

Authors:  Antonella Sistigu; Takahiro Yamazaki; Erika Vacchelli; Kariman Chaba; David P Enot; Julien Adam; Ilio Vitale; Aicha Goubar; Elisa E Baracco; Catarina Remédios; Laetitia Fend; Dalil Hannani; Laetitia Aymeric; Yuting Ma; Mireia Niso-Santano; Oliver Kepp; Joachim L Schultze; Thomas Tüting; Filippo Belardelli; Laura Bracci; Valentina La Sorsa; Giovanna Ziccheddu; Paola Sestili; Francesca Urbani; Mauro Delorenzi; Magali Lacroix-Triki; Virginie Quidville; Rosa Conforti; Jean-Philippe Spano; Lajos Pusztai; Vichnou Poirier-Colame; Suzette Delaloge; Frederique Penault-Llorca; Sylvain Ladoire; Laurent Arnould; Joanna Cyrta; Marie-Charlotte Dessoliers; Alexander Eggermont; Marco E Bianchi; Mikael Pittet; Camilla Engblom; Christina Pfirschke; Xavier Préville; Gilles Uzè; Robert D Schreiber; Melvyn T Chow; Mark J Smyth; Enrico Proietti; Fabrice André; Guido Kroemer; Laurence Zitvogel
Journal:  Nat Med       Date:  2014-10-26       Impact factor: 53.440

2.  An immunosurveillance mechanism controls cancer cell ploidy.

Authors:  Laura Senovilla; Ilio Vitale; Isabelle Martins; Maximilien Tailler; Claire Pailleret; Mickaël Michaud; Lorenzo Galluzzi; Sandy Adjemian; Oliver Kepp; Mireia Niso-Santano; Shensi Shen; Guillermo Mariño; Alfredo Criollo; Alice Boilève; Bastien Job; Sylvain Ladoire; François Ghiringhelli; Antonella Sistigu; Takahiro Yamazaki; Santiago Rello-Varona; Clara Locher; Vichnou Poirier-Colame; Monique Talbot; Alexander Valent; Francesco Berardinelli; Antonio Antoccia; Fabiola Ciccosanti; Gian Maria Fimia; Mauro Piacentini; Antonio Fueyo; Nicole L Messina; Ming Li; Christopher J Chan; Verena Sigl; Guillaume Pourcher; Christoph Ruckenstuhl; Didac Carmona-Gutierrez; Vladimir Lazar; Josef M Penninger; Frank Madeo; Carlos López-Otín; Mark J Smyth; Laurence Zitvogel; Maria Castedo; Guido Kroemer
Journal:  Science       Date:  2012-09-28       Impact factor: 47.728

3.  STAT3 Inhibition Enhances the Therapeutic Efficacy of Immunogenic Chemotherapy by Stimulating Type 1 Interferon Production by Cancer Cells.

Authors:  Heng Yang; Takahiro Yamazaki; Federico Pietrocola; Heng Zhou; Laurence Zitvogel; Yuting Ma; Guido Kroemer
Journal:  Cancer Res       Date:  2015-07-24       Impact factor: 12.701

Review 4.  Mechanism of action of conventional and targeted anticancer therapies: reinstating immunosurveillance.

Authors:  Laurence Zitvogel; Lorenzo Galluzzi; Mark J Smyth; Guido Kroemer
Journal:  Immunity       Date:  2013-07-25       Impact factor: 31.745

5.  Cytoplasmic STAT3 represses autophagy by inhibiting PKR activity.

Authors:  Shensi Shen; Mireia Niso-Santano; Sandy Adjemian; Tetsuo Takehara; Shoaib Ahmad Malik; Hervé Minoux; Sylvie Souquere; Guillermo Mariño; Sylvie Lachkar; Laura Senovilla; Lorenzo Galluzzi; Oliver Kepp; Gérard Pierron; Maria Chiara Maiuri; Hayato Hikita; Romano Kroemer; Guido Kroemer
Journal:  Mol Cell       Date:  2012-10-17       Impact factor: 17.970

Review 6.  Consensus guidelines for the detection of immunogenic cell death.

Authors:  Oliver Kepp; Laura Senovilla; Ilio Vitale; Erika Vacchelli; Sandy Adjemian; Patrizia Agostinis; Lionel Apetoh; Fernando Aranda; Vincenzo Barnaba; Norma Bloy; Laura Bracci; Karine Breckpot; David Brough; Aitziber Buqué; Maria G Castro; Mara Cirone; Maria I Colombo; Isabelle Cremer; Sandra Demaria; Luciana Dini; Aristides G Eliopoulos; Alberto Faggioni; Silvia C Formenti; Jitka Fučíková; Lucia Gabriele; Udo S Gaipl; Jérôme Galon; Abhishek Garg; François Ghiringhelli; Nathalia A Giese; Zong Sheng Guo; Akseli Hemminki; Martin Herrmann; James W Hodge; Stefan Holdenrieder; Jamie Honeychurch; Hong-Min Hu; Xing Huang; Tim M Illidge; Koji Kono; Mladen Korbelik; Dmitri V Krysko; Sherene Loi; Pedro R Lowenstein; Enrico Lugli; Yuting Ma; Frank Madeo; Angelo A Manfredi; Isabelle Martins; Domenico Mavilio; Laurie Menger; Nicolò Merendino; Michael Michaud; Gregoire Mignot; Karen L Mossman; Gabriele Multhoff; Rudolf Oehler; Fabio Palombo; Theocharis Panaretakis; Jonathan Pol; Enrico Proietti; Jean-Ehrland Ricci; Chiara Riganti; Patrizia Rovere-Querini; Anna Rubartelli; Antonella Sistigu; Mark J Smyth; Juergen Sonnemann; Radek Spisek; John Stagg; Abdul Qader Sukkurwala; Eric Tartour; Andrew Thorburn; Stephen H Thorne; Peter Vandenabeele; Francesca Velotti; Samuel T Workenhe; Haining Yang; Wei-Xing Zong; Laurence Zitvogel; Guido Kroemer; Lorenzo Galluzzi
Journal:  Oncoimmunology       Date:  2014-12-13       Impact factor: 8.110

7.  EGFR-mediated tumor immunoescape: The imbalance between phosphorylated STAT1 and phosphorylated STAT3.

Authors:  Fernando Concha-Benavente; Raghvendra M Srivastava; Soldano Ferrone; Robert L Ferris
Journal:  Oncoimmunology       Date:  2013-12-05       Impact factor: 8.110

8.  Immune-related gene signatures predict the outcome of neoadjuvant chemotherapy.

Authors:  Gautier Stoll; David Enot; Bernhard Mlecnik; Jérôme Galon; Laurence Zitvogel; Guido Kroemer
Journal:  Oncoimmunology       Date:  2014-02-27       Impact factor: 8.110

9.  Involvement of STAT3 in immune evasion during lung tumorigenesis.

Authors:  Hiroshi Kida; Shoichi Ihara; Atsushi Kumanogoh
Journal:  Oncoimmunology       Date:  2013-01-01       Impact factor: 8.110

10.  Screening of novel immunogenic cell death inducers within the NCI Mechanistic Diversity Set.

Authors:  Abdul Qader Sukkurwala; Sandy Adjemian; Laura Senovilla; Mickaël Michaud; Sabrina Spaggiari; Erika Vacchelli; Elisa Elena Baracco; Lorenzo Galluzzi; Laurence Zitvogel; Oliver Kepp; Guido Kroemer
Journal:  Oncoimmunology       Date:  2014-04-16       Impact factor: 8.110
  10 in total
  5 in total

1.  IL-15 enhances the antitumor effect of human antigen-specific CD8+ T cells by cellular senescence delay.

Authors:  Jinsheng Weng; Kelsey E Moriarty; Flavio Egidio Baio; Fuliang Chu; Sung-Doo Kim; Jin He; Zuliang Jie; Xiaoping Xie; Wencai Ma; Jianfei Qian; Liang Zhang; Jing Yang; Qing Yi; Sattva S Neelapu; Larry W Kwak
Journal:  Oncoimmunology       Date:  2016-10-07       Impact factor: 8.110

2.  STAT3 Contributes To Oncolytic Newcastle Disease Virus-Induced Immunogenic Cell Death in Melanoma Cells.

Authors:  Xiaoyan Shao; Xueke Wang; Xianling Guo; Ke Jiang; Tian Ye; Jianhua Chen; Juemin Fang; Linaer Gu; Sitong Wang; Guirong Zhang; Songshu Meng; Qing Xu
Journal:  Front Oncol       Date:  2019-05-29       Impact factor: 6.244

3.  Sequential Interferon β-Cisplatin Treatment Enhances the Surface Exposure of Calreticulin in Cancer Cells via an Interferon Regulatory Factor 1-Dependent Manner.

Authors:  Pei-Ming Yang; Yao-Yu Hsieh; Jia-Ling Du; Shih-Chieh Yen; Chien-Fu Hung
Journal:  Biomolecules       Date:  2020-04-21

4.  Targeting STAT3 enhances NDV-induced immunogenic cell death in prostate cancer cells.

Authors:  Xueke Wang; Xiaoyan Shao; Linaer Gu; Ke Jiang; Sitong Wang; Jianhua Chen; Juemin Fang; Xianling Guo; Min Yuan; Ji Shi; Chan Ding; Songshu Meng; Qing Xu
Journal:  J Cell Mol Med       Date:  2020-02-26       Impact factor: 5.310

5.  Targeted inhibition of STAT3 induces immunogenic cell death of hepatocellular carcinoma cells via glycolysis.

Authors:  Ya Li; Zhenwei Song; Qiuju Han; Huajun Zhao; Zhaoyi Pan; Zhengyang Lei; Jian Zhang
Journal:  Mol Oncol       Date:  2022-06-27       Impact factor: 7.449
  5 in total

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