Mary E Larkin1, Natalie Walders-Abramson2, Kathryn Hirst3, Joyce Keady4, Carolyn E Ievers-Landis5, Elizabeth M Venditti6, Patrice M Yasuda7. 1. 50 Staniford St, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA. 2. Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, CO, USA. 3. George Washington University Biostatistics Center, 6110 Executive Boulevard, Suite 750, Rockville, MD, USA. 4. Joslin Diabetes Center, One Joslin Place, Boston, MA, USA. 5. University Hospitals Rainbow Babies & Children's Hospital/Case Western Reserve University School of Medicine, 10524 Euclid Avenue, Cleveland, OH, USA. 6. Western Psychiatric Institute & Clinic University of Pittsburgh School of Medicine, 3811 O'Hara St, Pittsburgh, PA, USA. 7. Children's Hospital Los Angeles & Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
Abstract
AIM: To explore associations between health-related quality of life (HRQOL) and comorbidities in youth with Type 2 diabetes. PATIENTS & METHODS: Of 699 youth in the TODAY study, 685 (98%) had baseline HRQOL data, 649 (93%) at 6 months and 583 (83%) at 24 months. Comorbidities were defined by sustained abnormal values and treatment regimens. RESULTS: At baseline, 22.2% of participants demonstrated impaired HRQOL. Only depressive symptoms distinguished those with versus without impaired HRQOL and were significantly related to later impaired HRQOL (p < 0.0001). A significant correspondence between impaired HRQOL and number of comorbidities (p = 0.0003) was noted, but was driven by the presence of depressive symptoms. CONCLUSION: Results emphasize the need for evaluation of depressive symptoms. Other comorbidities did not have a significant impact on HRQOL in this cohort.
AIM: To explore associations between health-related quality of life (HRQOL) and comorbidities in youth with Type 2 diabetes. PATIENTS & METHODS: Of 699 youth in the TODAY study, 685 (98%) had baseline HRQOL data, 649 (93%) at 6 months and 583 (83%) at 24 months. Comorbidities were defined by sustained abnormal values and treatment regimens. RESULTS: At baseline, 22.2% of participants demonstrated impaired HRQOL. Only depressive symptoms distinguished those with versus without impaired HRQOL and were significantly related to later impaired HRQOL (p < 0.0001). A significant correspondence between impaired HRQOL and number of comorbidities (p = 0.0003) was noted, but was driven by the presence of depressive symptoms. CONCLUSION: Results emphasize the need for evaluation of depressive symptoms. Other comorbidities did not have a significant impact on HRQOL in this cohort.
Entities:
Keywords:
health-related quality of life; hyperlipidemia; hypertension; microalbuminuria; pediatric Type 2 diabetes
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