Literature DB >> 27056623

Transcranial direct current stimulation for acute major depressive episodes: meta-analysis of individual patient data.

André R Brunoni1, Adriano H Moffa2, Felipe Fregni2, Ulrich Palm2, Frank Padberg2, Daniel M Blumberger2, Zafiris J Daskalakis2, Djamila Bennabi2, Emmanuel Haffen2, Angelo Alonzo2, Colleen K Loo2.   

Abstract

BACKGROUND: Transcranial direct current stimulation (tDCS) is a non-pharmacological intervention for depression. It has mixed results, possibly caused by study heterogeneity. AIMS: To assess tDCS efficacy and to explore individual response predictors.
METHOD: Systematic review and individual patient data meta-analysis.
RESULTS: Data were gathered from six randomised sham-controlled trials, enrolling 289 patients. Active tDCS was significantly superior to sham for response (34% v. 19% respectively, odds ratio (OR) = 2.44, 95% CI 1.38-4.32, number needed to treat (NNT) = 7), remission (23.1% v. 12.7% respectively, OR = 2.38, 95% CI 1.22-4.64, NNT = 9) and depression improvement (B coefficient 0.35, 95% CI 0.12-0.57). Mixed-effects models showed that, after adjustment for other predictors and confounders, treatment-resistant depression and higher tDCS 'doses' were, respectively, negatively and positively associated with tDCS efficacy.
CONCLUSIONS: The effect size of tDCS treatment was comparable with those reported for repetitive transcranial magnetic stimulation and antidepressant drug treatment in primary care. The most important parameters for optimisation in future trials are depression refractoriness and tDCS dose. © The Royal College of Psychiatrists 2016.

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Year:  2016        PMID: 27056623      PMCID: PMC4887722          DOI: 10.1192/bjp.bp.115.164715

Source DB:  PubMed          Journal:  Br J Psychiatry        ISSN: 0007-1250            Impact factor:   9.319


  38 in total

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Authors:  Natalie A de Morton
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3.  Pilot study of feasibility of the effect of treatment with tDCS in patients suffering from treatment-resistant depression treated with escitalopram.

Authors:  D Bennabi; M Nicolier; J Monnin; G Tio; L Pazart; P Vandel; E Haffen
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Review 4.  Transcranial direct current stimulation for major depression: an updated systematic review and meta-analysis.

Authors:  Pedro Shiozawa; Felipe Fregni; Isabela M Benseñor; Paulo A Lotufo; Marcelo T Berlim; Jeff Z Daskalakis; Quirino Cordeiro; André R Brunoni
Journal:  Int J Neuropsychopharmacol       Date:  2014-04-08       Impact factor: 5.176

5.  A randomized, double-blind clinical trial on the efficacy of cortical direct current stimulation for the treatment of major depression.

Authors:  Paulo S Boggio; Sergio P Rigonatti; Rafael B Ribeiro; Martin L Myczkowski; Michael A Nitsche; Alvaro Pascual-Leone; Felipe Fregni
Journal:  Int J Neuropsychopharmacol       Date:  2007-06-11       Impact factor: 5.176

6.  A double-blind, sham-controlled trial of transcranial direct current stimulation for the treatment of depression.

Authors:  Colleen K Loo; Perminder Sachdev; Donel Martin; Melissa Pigot; Angelo Alonzo; Gin S Malhi; Jim Lagopoulos; Philip Mitchell
Journal:  Int J Neuropsychopharmacol       Date:  2009-08-12       Impact factor: 5.176

7.  Bupropion-SR, sertraline, or venlafaxine-XR after failure of SSRIs for depression.

Authors:  A John Rush; Madhukar H Trivedi; Stephen R Wisniewski; Jonathan W Stewart; Andrew A Nierenberg; Michael E Thase; Louise Ritz; Melanie M Biggs; Diane Warden; James F Luther; Kathy Shores-Wilson; George Niederehe; Maurizio Fava
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Review 8.  Antidepressants versus placebo for depression in primary care.

Authors:  Bruce Arroll; C Raina Elley; Tana Fishman; Felicity A Goodyear-Smith; Tim Kenealy; Grant Blashki; Ngaire Kerse; Stephen Macgillivray
Journal:  Cochrane Database Syst Rev       Date:  2009-07-08

9.  Impact of two or less missing treatment sessions on tDCS clinical efficacy: results from a factorial, randomized, controlled trial in major depression.

Authors:  Tamires A Zanão; Adriano H Moffa; Pedro Shiozawa; Paulo A Lotufo; Isabela M Benseñor; André R Brunoni
Journal:  Neuromodulation       Date:  2014-04-11

10.  Individual participant data meta-analysis for a binary outcome: one-stage or two-stage?

Authors:  Thomas P A Debray; Karel G M Moons; Ghada Mohammed Abdallah Abo-Zaid; Hendrik Koffijberg; Richard David Riley
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  81 in total

1.  Efficacy and Safety of Transcranial Direct Current Stimulation for Treating Negative Symptoms in Schizophrenia: A Randomized Clinical Trial.

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Review 2.  Transcranial electrical stimulation nomenclature.

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Journal:  Brain Stimul       Date:  2019-07-17       Impact factor: 8.955

Review 3.  Low-Intensity Transcranial Current Stimulation in Psychiatry.

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Review 4.  Pharmacogenetics and Imaging-Pharmacogenetics of Antidepressant Response: Towards Translational Strategies.

Authors:  Tristram A Lett; Henrik Walter; Eva J Brandl
Journal:  CNS Drugs       Date:  2016-12       Impact factor: 5.749

Review 5.  Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder: Section 4. Neurostimulation Treatments.

Authors:  Roumen V Milev; Peter Giacobbe; Sidney H Kennedy; Daniel M Blumberger; Zafiris J Daskalakis; Jonathan Downar; Mandana Modirrousta; Simon Patry; Fidel Vila-Rodriguez; Raymond W Lam; Glenda M MacQueen; Sagar V Parikh; Arun V Ravindran
Journal:  Can J Psychiatry       Date:  2016-08-02       Impact factor: 4.356

Review 6.  Transcranial magnetic stimulation, deep brain stimulation, and other forms of neuromodulation for substance use disorders: Review of modalities and implications for treatment.

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7.  Acute and repetitive fronto-cerebellar tDCS stimulation improves mood in non-depressed participants.

Authors:  Simon Newstead; Hayley Young; David Benton; Gabriela Jiga-Boy; Maria L Andrade Sienz; R M Clement; Frédéric Boy
Journal:  Exp Brain Res       Date:  2017-11-02       Impact factor: 1.972

Review 8.  Incomplete evidence that increasing current intensity of tDCS boosts outcomes.

Authors:  Zeinab Esmaeilpour; Paola Marangolo; Benjamin M Hampstead; Sven Bestmann; Elisabeth Galletta; Helena Knotkova; Marom Bikson
Journal:  Brain Stimul       Date:  2017-12-13       Impact factor: 8.955

Review 9.  Electrical stimulation of cranial nerves in cognition and disease.

Authors:  Devin Adair; Dennis Truong; Zeinab Esmaeilpour; Nigel Gebodh; Helen Borges; Libby Ho; J Douglas Bremner; Bashar W Badran; Vitaly Napadow; Vincent P Clark; Marom Bikson
Journal:  Brain Stimul       Date:  2020-02-23       Impact factor: 8.955

Review 10.  Brain metabolism in health, aging, and neurodegeneration.

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Journal:  EMBO J       Date:  2017-04-24       Impact factor: 11.598

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