Literature DB >> 27056543

Force Matters: Biomechanical Regulation of Cell Invasion and Migration in Disease.

FuiBoon Kai1, Hanane Laklai1, Valerie M Weaver2.   

Abstract

Atherosclerosis, cancer, and various chronic fibrotic conditions are characterized by an increase in the migratory behavior of resident cells and the enhanced invasion of assorted exogenous cells across a stiffened extracellular matrix (ECM). This stiffened scaffold aberrantly engages cellular mechanosignaling networks in cells, which promotes the assembly of invadosomes and lamellae for cell invasion and migration. Accordingly, deciphering the conserved molecular mechanisms whereby matrix stiffness fosters invadosome and lamella formation could identify therapeutic targets to treat fibrotic conditions, and reducing ECM stiffness could ameliorate disease progression. Published by Elsevier Ltd.

Entities:  

Keywords:  cancer; cardiovascular disease; extracellular matrix stiffness; fibrosis; invasion; migration

Mesh：

Year:  2016        PMID： 27056543      PMCID： PMC4970516          DOI： 10.1016/j.tcb.2016.03.007

Source DB:  PubMed          Journal:  Trends Cell Biol        ISSN： 0962-8924            Impact factor:   20.808


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