Literature DB >> 27056087

Synthesis of 3-fluoroalkenyl-3-trifluoromethyl-2-oxindoles by the reaction of indoline-2,3-diones with difluoromethylene phosphabetaine.

Yingle Liu1, Ke Zhang, Yangen Huang, Shen Pan, Xiao-Qiang Liu, Yi Yang, Yan Jiang, Xiu-Hua Xu.   

Abstract

An unprecedent reaction of indoline-2,3-diones and (triphenylphosphonio)difluoroacetate (PDFA) afforded novel 3-fluoroalkenyl-3-trifluoromethyl-2-oxindoles in moderate to excellent yields. These products could be transformed into other trifluoromethylated oxindole derivatives.

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Year:  2016        PMID： 27056087     DOI： 10.1039/c6cc00666c

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  2 in total

1.  An Unconventional Mechanistic Insight into SCF3 Formation from Difluorocarbene: Preparation of 18 F-Labeled α-SCF3 Carbonyl Compounds.

Authors:  Jian Zheng; Ran Cheng; Jin-Hong Lin; Dong-Hai Yu; Longle Ma; Lina Jia; Lan Zhang; Lu Wang; Ji-Chang Xiao; Steven H Liang
Journal:  Angew Chem Int Ed Engl       Date:  2017-02-14       Impact factor: 15.336

2.  Highly stereoselective nickel-catalyzed difluoroalkylation of aryl ketones to tetrasubstituted monofluoroalkenes and quaternary alkyl difluorides.

Authors:  Chao Li; Yi-Xuan Cao; Ruo-Xing Jin; Kang-Jie Bian; Zi-Yang Qin; Quan Lan; Xi-Sheng Wang
Journal:  Chem Sci       Date:  2019-08-20       Impact factor: 9.825
  2 in total

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