PURPOSE: To investigate oncological outcomes in patients with muscle-invasive bladder cancer who underwent open radical cystectomy (ORC), laparoscopic radical cystectomy (LRC), or robot-assisted radical cystectomy (RARC). PATIENTS AND METHODS: A retrospective analysis was performed on 230 patients who underwent ORC (n = 150), LRC (n = 22), or RARC (n = 58) between September 2009 and June 2012. Perioperative outcomes were compared between the three surgical approaches. The influence of the type of surgical approach on recurrence-free survival (RFS), cancer-specific survival (CSS), and overall survival (OS) was analyzed using the Kaplan-Meier method, and differences were assessed with the log-rank test. Predictors of RFS, CSS, and OS were also analyzed with a Cox regression model. RESULTS: The median patient age for ORC, LRC, and RARC groups was 68.0 (interquartile range [IQR]: 60.0-73.0), 65.0 (IQR: 62.8-74.0), and 61.5 (IQR: 54.8-72.0) years, respectively (p = 0.017), and the median follow-up duration was 27.9 (IQR: 14.7-47.9), 28.8 (IQR: 15.7-41.8), and 32.0 (IQR: 15.5-45.4) months, respectively (p = 0.955). There was no significant difference in RFS, CSS, and OS according to the surgical approach (p = 0.253, p = 0.431, and p = 0.527, respectively). Subgroup analysis revealed that RFS, CSS, and OS were not significantly different in both subgroups with stage ≤pT2 or ≥pT3. Multivariable Cox regression analyses showed that the surgical approach was not a significant predictor of RFS, CSS, and OS. CONCLUSION: Our findings indicate that the type of surgical approach is not associated with RFS, CSS, and OS in patients with bladder cancer.
PURPOSE: To investigate oncological outcomes in patients with muscle-invasive bladder cancer who underwent open radical cystectomy (ORC), laparoscopic radical cystectomy (LRC), or robot-assisted radical cystectomy (RARC). PATIENTS AND METHODS: A retrospective analysis was performed on 230 patients who underwent ORC (n = 150), LRC (n = 22), or RARC (n = 58) between September 2009 and June 2012. Perioperative outcomes were compared between the three surgical approaches. The influence of the type of surgical approach on recurrence-free survival (RFS), cancer-specific survival (CSS), and overall survival (OS) was analyzed using the Kaplan-Meier method, and differences were assessed with the log-rank test. Predictors of RFS, CSS, and OS were also analyzed with a Cox regression model. RESULTS: The median patient age for ORC, LRC, and RARC groups was 68.0 (interquartile range [IQR]: 60.0-73.0), 65.0 (IQR: 62.8-74.0), and 61.5 (IQR: 54.8-72.0) years, respectively (p = 0.017), and the median follow-up duration was 27.9 (IQR: 14.7-47.9), 28.8 (IQR: 15.7-41.8), and 32.0 (IQR: 15.5-45.4) months, respectively (p = 0.955). There was no significant difference in RFS, CSS, and OS according to the surgical approach (p = 0.253, p = 0.431, and p = 0.527, respectively). Subgroup analysis revealed that RFS, CSS, and OS were not significantly different in both subgroups with stage ≤pT2 or ≥pT3. Multivariable Cox regression analyses showed that the surgical approach was not a significant predictor of RFS, CSS, and OS. CONCLUSION: Our findings indicate that the type of surgical approach is not associated with RFS, CSS, and OS in patients with bladder cancer.
Authors: Amandeep Arora; Felipe Pugliesi; Ahmed S Zugail; Marco Moschini; Cristiano Pazeto; Petr Macek; Armando Stabile; Camille Lanz; Nathalie Cathala; Mostefa Bennamoun; Rafael Sanchez-Salas; Xavier Cathelineau Journal: Arab J Urol Date: 2020-10-01
Authors: Angelo Porreca; Katie Palmer; Walter Artibani; Alessandro Antonelli; Lorenzo Bianchi; Eugenio Brunocilla; Aldo Massimo Bocciardi; Maurizio Brausi; Gian Maria Busetto; Marco Carini; Giuseppe Carrieri; Antonio Celia; Luca Cindolo; Giovanni Cochetti; Renzo Colombo; Ettore De Berardinis; Ottavio De Cobelli; Fabrizio Di Maida; Amelio Ercolino; Franco Gaboardi; Antonio Galfano; Andrea Gallina; Michele Gallucci; Carlo Introini; Ettore Mearini; Andrea Minervini; Francesco Montorsi; Gennaro Musi; Giovannalberto Pini; Riccardo Schiavina; Silvia Secco; Sergio Serni; Claudio Simeone; Giovanni Tasso; Daniele D'Agostino Journal: BMC Cancer Date: 2021-01-11 Impact factor: 4.430
Authors: Lin Dong; Yu Qin; Lu Ya; Cao Liang; Hu Tinghui; He Pinlin; Yang Jin; Wang Youliang; Cui Shu; Wu Tao Journal: Medicine (Baltimore) Date: 2020-12-24 Impact factor: 1.817