Literature DB >> 27055378

Bombesin-Like Receptor 3: Physiology of a Functional Orphan.

Cuiying Xiao1, Marc L Reitman2.   

Abstract

Bombesin-like receptor 3 (BRS-3) is an X-linked orphan Gq-coupled receptor that regulates food intake, metabolic rate, body temperature, heart rate, blood pressure, and insulin secretion. Most BRS-3 actions occur via the brain, through mechanisms including regulating sympathetic outflow. Ablation of Brs3 causes obesity, while synthetic agonists produce weight loss. Published by Elsevier Ltd.

Entities:  

Keywords:  blood pressure; energy expenditure; food intake; heart rate; insulin secretion; sympathetic tone

Mesh：

Substances：

Year:  2016        PMID： 27055378      PMCID： PMC4992652          DOI： 10.1016/j.tem.2016.03.003

Source DB:  PubMed          Journal:  Trends Endocrinol Metab        ISSN： 1043-2760            Impact factor:   12.015


  14 in total

1.  Pharmacokinetics and pharmacodynamics of MK-5046, a bombesin receptor subtype-3 (BRS-3) agonist, in healthy patients.

Authors:  Marc L Reitman; Victor Dishy; Allison Moreau; William S Denney; Chengcheng Liu; Walter K Kraft; Alex V Mejia; Mark A Matson; S Aubrey Stoch; John A Wagner; Eseng Lai
Journal:  J Clin Pharmacol       Date:  2011-12-12       Impact factor: 3.126

2.  Role of bombesin (BN)-like peptides/receptors in emotional behavior by comparison of three strains of BN-like peptide receptor knockout mice.

Authors:  K Yamada; Y Santo-Yamada; E Wada; K Wada
Journal:  Mol Psychiatry       Date:  2002       Impact factor: 15.992

Review 3.  Bombesin receptor subtype 3 as a potential target for obesity and diabetes.

Authors:  Nieves González; Paola Moreno; Robert T Jensen
Journal:  Expert Opin Ther Targets       Date:  2015-06-12       Impact factor: 6.902

Review 4.  G protein-coupled receptor deorphanizations.

Authors:  Olivier Civelli; Rainer K Reinscheid; Yan Zhang; Zhiwei Wang; Robert Fredriksson; Helgi B Schiöth
Journal:  Annu Rev Pharmacol Toxicol       Date:  2012-09-28       Impact factor: 13.820

5.  Bombesin receptor subtype-3 (BRS-3) regulates glucose-stimulated insulin secretion in pancreatic islets across multiple species.

Authors:  Yue Feng; Xiao-Ming Guan; Jing Li; Joseph M Metzger; Yonghua Zhu; Kirstine Juhl; Bei B Zhang; Nancy A Thornberry; Marc L Reitman; Yun-Ping Zhou
Journal:  Endocrinology       Date:  2011-08-30       Impact factor: 4.736

6.  Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity.

Authors:  H Ohki-Hamazaki; K Watase; K Yamamoto; H Ogura; M Yamano; K Yamada; H Maeno; J Imaki; S Kikuyama; E Wada; K Wada
Journal:  Nature       Date:  1997-11-13       Impact factor: 49.962

7.  Factors contributing to obesity in bombesin receptor subtype-3-deficient mice.

Authors:  Ellen E Ladenheim; Nahketah L Hamilton; Robert R Behles; Sheng Bi; Lori L Hampton; James F Battey; Timothy H Moran
Journal:  Endocrinology       Date:  2007-11-26       Impact factor: 4.736

8.  Bombesin-like receptor 3 regulates blood pressure and heart rate via a central sympathetic mechanism.

Authors:  Dalya M Lateef; Cuiying Xiao; Robert J Brychta; André Diedrich; Jurgen Schnermann; Marc L Reitman
Journal:  Am J Physiol Heart Circ Physiol       Date:  2016-01-22       Impact factor: 4.733

9.  Molecular basis for agonism in the BB3 receptor: an epitope located on the interface of transmembrane-III, -VI, and -VII.

Authors:  F Gbahou; B Holst; T W Schwartz
Journal:  J Pharmacol Exp Ther       Date:  2010-01-11       Impact factor: 4.030

10.  Human BRS-3 receptor: functions/role in cell signaling pathways and glucose metabolism in obese or diabetic myocytes.

Authors:  I Ramos-Álvarez; Z Moreno-Villegas; A Martín-Duce; R Sanz; C Aparicio; S Portal-Núñez; S A Mantey; R T Jensen; N González
Journal:  Peptides       Date:  2013-11-09       Impact factor: 3.750
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  16 in total

1.  Receptor-specific crosstalk between prostanoid E receptor 3 and bombesin receptor subtype 3.

Authors:  Yan Zhang; Yanfang Liu; Lehao Wu; Chao Fan; Zhiwei Wang; Xiuli Zhang; Amal Alachkar; Xinmiao Liang; Olivier Civelli
Journal:  FASEB J       Date:  2018-01-22       Impact factor: 5.191

Review 2.  Radiolabeled bombesin derivatives for preclinical oncological imaging.

Authors:  Carolina de Aguiar Ferreira; Leonardo Lima Fuscaldi; Danyelle M Townsend; Domenico Rubello; André Luís Branco de Barros
Journal:  Biomed Pharmacother       Date:  2016-12-29       Impact factor: 6.529

3.  Development and Characterization of a Novel, High-Affinity, Specific, Radiolabeled Ligand for BRS-3 Receptors.

Authors:  Irene Ramos-Alvarez; Lingaku Lee; Samuel A Mantey; Robert T Jensen
Journal:  J Pharmacol Exp Ther       Date:  2019-04-10       Impact factor: 4.030

4.  Agonist-induced extracellular vesicles contribute to the transfer of functional bombesin receptor-subtype 3 to recipient cells.

Authors:  Zeyuan Wang; Lehao Wu; Huiyu Wang; Yan Zhang; Hua Xiao
Journal:  Cell Mol Life Sci       Date:  2022-01-15       Impact factor: 9.261

5.  The Nonpeptide Agonist MK-5046 Functions As an Allosteric Agonist for the Bombesin Receptor Subtype-3.

Authors:  Irene Ramos-Alvarez; Tatiana Iordanskaia; Samuel A Mantey; Robert T Jensen
Journal:  J Pharmacol Exp Ther       Date:  2022-05-29       Impact factor: 4.402

6.  Preoptic BRS3 neurons increase body temperature and heart rate via multiple pathways.

Authors:  Ramón A Piñol; Allison S Mogul; Colleen K Hadley; Atreyi Saha; Chia Li; Vojtěch Škop; Haley S Province; Cuiying Xiao; Oksana Gavrilova; Michael J Krashes; Marc L Reitman
Journal:  Cell Metab       Date:  2021-05-25       Impact factor: 31.373

7.  Bombesin receptor subtype-3-expressing neurons regulate energy homeostasis through a novel neuronal pathway in the hypothalamus.

Authors:  Minoru Maruyama; Natsu Hotta; Yasunori Nio; Kenichi Hamagami; Toshimi Nagi; Masaaki Funata; Junichi Sakamoto; Masanori Nakakariya; Nobuyuki Amano; Mayumi Nishida; Tomohiro Okawa; Yasuyoshi Arikawa; Shinobu Sasaki; Shizuo Kasai; Yasutaka Nagisa; Yugo Habata; Masaaki Mori
Journal:  Brain Behav       Date:  2017-12-15       Impact factor: 2.708

8.  The gastrin-releasing peptide/bombesin system revisited by a reverse-evolutionary study considering Xenopus.

Authors:  Asuka Hirooka; Mayuko Hamada; Daiki Fujiyama; Keiko Takanami; Yasuhisa Kobayashi; Takumi Oti; Yukitoshi Katayama; Tatsuya Sakamoto; Hirotaka Sakamoto
Journal:  Sci Rep       Date:  2021-06-25       Impact factor: 4.379

9.  Bombesin-like receptor 3 (Brs3) expression in glutamatergic, but not GABAergic, neurons is required for regulation of energy metabolism.

Authors:  Cuiying Xiao; Ramón A Piñol; Jesse Lea Carlin; Cuiling Li; Chuxia Deng; Oksana Gavrilova; Marc L Reitman
Journal:  Mol Metab       Date:  2017-09-15       Impact factor: 7.422

10.  Cre Recombinase Driver Mice Reveal Lineage-Dependent and -Independent Expression of Brs3 in the Mouse Brain.

Authors:  Allison S Mogul; Colleen K Hadley; Haley S Province; Jordan Pauli; Oksana Gavrilova; Cuiying Xiao; Richard D Palmiter; Ramón A Piñol; Marc L Reitman
Journal:  eNeuro       Date:  2021-08-17
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