Literature DB >> 2705471

The genetics of Crohn disease: complex segregation analysis of a family study with 265 patients with Crohn disease and 5,387 relatives.

W Küster1, L Pascoe, J Purrmann, S Funk, F Majewski.   

Abstract

We have analysed the pedigrees of 265 probands with Crohn disease, collected from a specialty clinic at the University of Düsseldorf. Complex segregation analysis suggests the presence of a recessive gene with incomplete penetrance for susceptibility to the disease with no residual causes of family resemblance. However, a proportion of the isolated cases are probably due to phenocopies, this proportion being greatest among cases with an advanced age of onset.

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Year:  1989        PMID： 2705471     DOI： 10.1002/ajmg.1320320122

Source DB:  PubMed          Journal:  Am J Med Genet        ISSN： 0148-7299


  25 in total

1.  Inflammatory bowel disease: definition, epidemiology, etiologic aspects, and immunogenetic studies.

Authors:  Bing Xia; JBA Crusius; SGM Meuwissen; AS Pe?a
Journal:  World J Gastroenterol       Date:  1998-10       Impact factor: 5.742

Review 2.  Genetic aspects of inflammatory bowel disease: how far have we come, and where are we heading?

Authors:  J Cho
Journal:  Curr Gastroenterol Rep       Date:  1999-12

Review 3.  Have genomic discoveries in inflammatory bowel disease translated into clinical progress?

Authors:  Adam V Weizman; Mark S Silverberg
Journal:  Curr Gastroenterol Rep       Date:  2012-04

4.  Genotype and phenotype relation in inflammatory bowel disease.

Authors:  Yoshitaka Kinouchi; Kenichi Negoro; Sho Takagi; Seiichi Takahashi; Tooru Shimosegawa
Journal:  J Gastroenterol       Date:  2005-03       Impact factor: 7.527

Review 5.  Family and twin studies in inflammatory bowel disease.

Authors:  Leena Halme; Paulina Paavola-Sakki; Ulla Turunen; Maarit Lappalainen; Martti Farkkila; Kimmo Kontula
Journal:  World J Gastroenterol       Date:  2006-06-21       Impact factor: 5.742

Review 6.  Genetics of inflammatory bowel disease: current status and future directions.

Authors:  Thomas D Walters; Mark S Silverberg
Journal:  Can J Gastroenterol       Date:  2006-10       Impact factor: 3.522

7.  Analysis of the contribution of HLA genes to genetic predisposition in inflammatory bowel disease.

Authors:  I Naom; J Lee; D Ford; S J Bowman; J S Lanchbury; I Haris; S V Hodgson; D Easton; J Lennard-Jones; C G Mathew
Journal:  Am J Hum Genet       Date:  1996-07       Impact factor: 11.025

8.  Family history of Crohn's disease is associated with an increased risk for Crohn's disease of the pouch.

Authors:  Bo Shen; Feza H Remzi; Jeffrey P Hammel; Bret A Lashner; Charles L Bevins; Ian C Lavery; Jan Wehkamp; Victor W Fazio
Journal:  Inflamm Bowel Dis       Date:  2009-02       Impact factor: 5.325

9.  T cell antigen receptor V gene usage. Increases in V beta 8+ T cells in Crohn's disease.

Authors:  D N Posnett; I Schmelkin; D A Burton; A August; H McGrath; L F Mayer
Journal:  J Clin Invest       Date:  1990-06       Impact factor: 14.808

Review 10.  Breastfeeding and genetic factors in the etiology of inflammatory bowel disease in children.

Authors:  Theresa A Mikhailov; Sylvia E Furner
Journal:  World J Gastroenterol       Date:  2009-01-21       Impact factor: 5.742
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