Literature DB >> 27054372

Methamphetamine Vaccines: Improvement through Hapten Design.

Karen C Collins1, Joel E Schlosburg1, Paul T Bremer1, Kim D Janda1.   

Abstract

Methamphetamine (MA) addiction is a serious public health problem, and current methods to abate addiction and relapse are currently ineffective for mitigating this growing global epidemic. Development of a vaccine targeting MA would provide a complementary strategy to existing behavioral therapies, but this has proven challenging. Herein, we describe optimization of both hapten design and formulation, identifying a vaccine that elicited a robust anti-MA immune response in mice, decreasing methamphetamine-induced locomotor activity.

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Year:  2016        PMID： 27054372      PMCID： PMC5895457          DOI： 10.1021/acs.jmedchem.6b00084

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  32 in total

1.  Determination of affinity and specificity of anti-hapten antibodies by competitive radioimmunoassay.

Authors:  R Müller
Journal:  Methods Enzymol       Date:  1983       Impact factor: 1.600

2.  Synthesis of mercapto-(+)-methamphetamine haptens and their use for obtaining improved epitope density on (+)-methamphetamine conjugate vaccines.

Authors:  F Ivy Carroll; Bruce E Blough; Ramakrishna R Pidaparthi; Philip Abraham; Paul K Gong; Liu Deng; Xiaodong Huang; Melinda Gunnell; Jackson O Lay; Eric C Peterson; S Michael Owens
Journal:  J Med Chem       Date:  2011-06-29       Impact factor: 7.446

3.  Generation of anti-(+)methamphetamine antibodies is not impeded by (+)methamphetamine administration during active immunization of rats.

Authors:  K A Byrnes-Blake; F I Carroll; P Abraham; S M Owens
Journal:  Int Immunopharmacol       Date:  2001-02       Impact factor: 4.932

Review 4.  Behavioral therapies for drug abuse.

Authors:  Kathleen M Carroll; Lisa S Onken
Journal:  Am J Psychiatry       Date:  2005-08       Impact factor: 18.112

5.  A methamphetamine vaccine attenuates methamphetamine-induced disruptions in thermoregulation and activity in rats.

Authors:  Michelle L Miller; Amira Y Moreno; Shawn M Aarde; Kevin M Creehan; Sophia A Vandewater; Brittani D Vaillancourt; M Jerry Wright; Kim D Janda; Michael A Taffe
Journal:  Biol Psychiatry       Date:  2012-10-23       Impact factor: 13.382

6.  Reduced antinociception of opioids in rats and mice by vaccination with immunogens containing oxycodone and hydrocodone haptens.

Authors:  Marco Pravetoni; Morgan Le Naour; Ashli M Tucker; Theresa M Harmon; Tara M Hawley; Philip S Portoghese; Paul R Pentel
Journal:  J Med Chem       Date:  2013-01-15       Impact factor: 7.446

Review 7.  Approaches to the development of medications for the treatment of methamphetamine dependence.

Authors:  Frank J Vocci; Nathan M Appel
Journal:  Addiction       Date:  2007-04       Impact factor: 6.526

8.  Measurement of protein using bicinchoninic acid.

Authors:  P K Smith; R I Krohn; G T Hermanson; A K Mallia; F H Gartner; M D Provenzano; E K Fujimoto; N M Goeke; B J Olson; D C Klenk
Journal:  Anal Biochem       Date:  1985-10       Impact factor: 3.365

Review 9.  The methamphetamine problem in the United States.

Authors:  Rachel Gonzales; Larissa Mooney; Richard A Rawson
Journal:  Annu Rev Public Health       Date:  2010       Impact factor: 21.981

10.  Investigating hapten clustering as a strategy to enhance vaccines against drugs of abuse.

Authors:  Karen C Collins; Kim D Janda
Journal:  Bioconjug Chem       Date:  2014-02-25       Impact factor: 4.774
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  12 in total

1.  Investigations into the efficacy of multi-component cocaine vaccines.

Authors:  Atsushi Kimishima; Margaret E Olson; Kim D Janda
Journal:  Bioorg Med Chem Lett       Date:  2017-12-20       Impact factor: 2.823

Review 2.  Conjugate Vaccine Immunotherapy for Substance Use Disorder.

Authors:  Paul T Bremer; Kim D Janda
Journal:  Pharmacol Rev       Date:  2017-07       Impact factor: 25.468

3.  Molecular Containers Bind Drugs of Abuse in Vitro and Reverse the Hyperlocomotive Effect of Methamphetamine in Rats.

Authors:  Shweta Ganapati; Stephanie D Grabitz; Steven Murkli; Flora Scheffenbichler; Maíra I Rudolph; Peter Y Zavalij; Matthias Eikermann; Lyle Isaacs
Journal:  Chembiochem       Date:  2017-07-12       Impact factor: 3.164

Review 4.  Psychopharmacology: neuroimmune signaling in psychiatric disease-developing vaccines against abused drugs using toll-like receptor agonists.

Authors:  Fang Yang; Thomas R Kosten
Journal:  Psychopharmacology (Berl)       Date:  2019-02-06       Impact factor: 4.530

5.  Inner Workings: Using vaccines to harness the immune system and fight drugs of abuse.

Authors:  Leah Shaffer
Journal:  Proc Natl Acad Sci U S A       Date:  2021-12-28       Impact factor: 11.205

6.  In Vitro and In Vivo Sequestration of Methamphetamine by a Sulfated Acyclic CB[n]-Type Receptor.

Authors:  Adam T Brockett; Chunlin Deng; Michael Shuster; Suvenika Perera; Delaney DiMaggio; Ming Cheng; Steven Murkli; Volker Briken; Matthew R Roesch; Lyle Isaacs
Journal:  Chemistry       Date:  2021-10-27       Impact factor: 5.236

Review 7.  Methamphetamine Dysregulation of the Central Nervous System and Peripheral Immunity.

Authors:  Douglas R Miller; Mengfei Bu; Adithya Gopinath; Luis R Martinez; Habibeh Khoshbouei
Journal:  J Pharmacol Exp Ther       Date:  2021-09-17       Impact factor: 4.402

8.  Influencing Antibody-Mediated Attenuation of Methamphetamine CNS Distribution through Vaccine Linker Design.

Authors:  Major Gooyit; Pedro O Miranda; Cody J Wenthur; Alex Ducime; Kim D Janda
Journal:  ACS Chem Neurosci       Date:  2016-12-16       Impact factor: 4.418

9.  Antibody production and pharmacokinetics of METH in rats following vaccination with the METH vaccine, IXT-v100, adjuvanted with GLA-SE.

Authors:  Misty W Stevens; Daniela Rüedi-Bettschen; Melinda G Gunnell; Rachel Tawney; C Michael West; S Michael Owens
Journal:  Drug Alcohol Depend       Date:  2019-08-30       Impact factor: 4.492

10.  In Vitro and In Vivo Sequestration of Phencyclidine by Me4 Cucurbit[8]uril*.

Authors:  Steven Murkli; Jared Klemm; Adam T Brockett; Michael Shuster; Volker Briken; Matthew R Roesch; Lyle Isaacs
Journal:  Chemistry       Date:  2021-01-19       Impact factor: 5.236
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