Andrew Mujugira1, Robert W Coombs2, Renee Heffron1, Connie Celum3, Allan Ronald4, Nelly Mugo5, Jared M Baeten3. 1. Department of Global Health Department of Epidemiology. 2. Department of Laboratory Medicine Department of Medicine, University of Washington, Seattle. 3. Department of Global Health Department of Epidemiology Department of Medicine, University of Washington, Seattle. 4. Department of Medicine Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada. 5. Department of Global Health Center for Clinical Research, Kenya Medical Research Institute, Nairobi.
Abstract
BACKGROUND: Intermittent shedding of human immunodeficiency virus type 1 (HIV) in semen occurs despite effective antiretroviral therapy (ART) and suppressed blood HIV-1 RNA levels. METHODS: We assessed the frequency, magnitude, and correlates of seminal HIV-1 RNA shedding in HIV-1-infected African men initiating ART. RESULTS:Seminal HIV-1 RNA was detected in 24% (37 of 155), 10% (5 of 49), and 11% (8 of 70) of samples collected 0-3, 4-6, and >6 months after ART initiation. When blood HIV-1 levels were suppressed, seminal HIV-1 RNA was detected in 8% (16 of 195), and 82% (13 of 16) had an HIV-1 RNA load of < 1000 copies/mL. CONCLUSIONS:Seminal HIV-1 RNA shedding was infrequent and present at low levels in HIV-1-infected African men with suppressed blood HIV-1 RNA.
RCT Entities:
BACKGROUND: Intermittent shedding of human immunodeficiency virus type 1 (HIV) in semen occurs despite effective antiretroviral therapy (ART) and suppressed blood HIV-1 RNA levels. METHODS: We assessed the frequency, magnitude, and correlates of seminal HIV-1 RNA shedding in HIV-1-infected African men initiating ART. RESULTS:Seminal HIV-1 RNA was detected in 24% (37 of 155), 10% (5 of 49), and 11% (8 of 70) of samples collected 0-3, 4-6, and >6 months after ART initiation. When blood HIV-1 levels were suppressed, seminal HIV-1 RNA was detected in 8% (16 of 195), and 82% (13 of 16) had an HIV-1 RNA load of < 1000 copies/mL. CONCLUSIONS:Seminal HIV-1 RNA shedding was infrequent and present at low levels in HIV-1-infected African men with suppressed blood HIV-1 RNA.
Authors: H Chakraborty; P K Sen; R W Helms; P L Vernazza; S A Fiscus; J J Eron; B K Patterson; R W Coombs; J N Krieger; M S Cohen Journal: AIDS Date: 2001-03-30 Impact factor: 4.177
Authors: P Gupta; C Leroux; B K Patterson; L Kingsley; C Rinaldo; M Ding; Y Chen; K Kulka; W Buchanan; B McKeon; R Montelaro Journal: J Infect Dis Date: 2000-06-29 Impact factor: 5.226
Authors: Jared M Baeten; Deborah Donnell; Nelly R Mugo; Patrick Ndase; Katherine K Thomas; James D Campbell; Jonathan Wangisi; Jordan W Tappero; Elizabeth A Bukusi; Craig R Cohen; Elly Katabira; Allan Ronald; Elioda Tumwesigye; Edwin Were; Kenneth H Fife; James Kiarie; Carey Farquhar; Grace John-Stewart; Lara Kidoguchi; Robert W Coombs; Craig Hendrix; Mark A Marzinke; Lisa Frenkel; Jessica E Haberer; David Bangsberg; Connie Celum Journal: Lancet Infect Dis Date: 2014-10-07 Impact factor: 25.071
Authors: Myron S Cohen; M Kumi Smith; Kathryn E Muessig; Timothy B Hallett; Kimberly A Powers; Angela D Kashuba Journal: Lancet Date: 2013-10-23 Impact factor: 79.321
Authors: Susan M Graham; Sarah E Holte; Joan A Dragavon; Kelly M Ramko; Kishor N Mandaliya; R Scott McClelland; Norbert M Peshu; Eduard J Sanders; John N Krieger; Robert W Coombs Journal: PLoS One Date: 2012-08-13 Impact factor: 3.240
Authors: Ashley A Leech; James F Burgess; Meg Sullivan; Wendy Kuohung; Michal Horný; Mari-Lynn Drainoni; Cindy L Christiansen; Benjamin P Linas Journal: AIDS Date: 2018-11-28 Impact factor: 4.177
Authors: Jorge Del Romero; María Begoña Baza; Isabel Río; Adrián Jerónimo; Mar Vera; Victoria Hernando; Carmen Rodríguez; Jesús Castilla Journal: Medicine (Baltimore) Date: 2016-07 Impact factor: 1.889
Authors: John T Brooks; Jennifer F Kawwass; Dawn K Smith; Dmitry M Kissin; Margaret Lampe; Lisa B Haddad; Sheree L Boulet; Denise J Jamieson Journal: MMWR Morb Mortal Wkly Rep Date: 2017-08-18 Impact factor: 17.586
Authors: Samuel Mundia Kariuki; Philippe Selhorst; Jennifer Norman; Karen Cohen; Kevin Rebe; Carolyn Williamson; Jeffrey R Dorfman Journal: Virol J Date: 2020-03-05 Impact factor: 4.099
Authors: Alison J Rodger; Valentina Cambiano; Tina Bruun; Pietro Vernazza; Simon Collins; Olaf Degen; Giulio Maria Corbelli; Vicente Estrada; Anna Maria Geretti; Apostolos Beloukas; Dorthe Raben; Pep Coll; Andrea Antinori; Nneka Nwokolo; Armin Rieger; Jan M Prins; Anders Blaxhult; Rainer Weber; Arne Van Eeden; Norbert H Brockmeyer; Amanda Clarke; Jorge Del Romero Guerrero; Francois Raffi; Johannes R Bogner; Gilles Wandeler; Jan Gerstoft; Felix Gutiérrez; Kees Brinkman; Maria Kitchen; Lars Ostergaard; Agathe Leon; Matti Ristola; Heiko Jessen; Hans-Jürgen Stellbrink; Andrew N Phillips; Jens Lundgren Journal: Lancet Date: 2019-05-02 Impact factor: 79.321