Literature DB >> 2705275

The effect on the cornea of alpha cyclodextrin vehicle for cyclosporin eye drops.

A Kanai1, R M Alba, T Takano, C Kobayashi, A Nakajima, K Kurihara, T Yokoyama, M Fukami.   

Abstract

We tested four different combinations of alpha-CD and CYA: 0.075% and 80 mg/mL alpha-CD, 0.025% CYA and 40 mg/mL alpha-CD, 0.009% CYA and 20 mg/mL alpha-CD, and 0.003% CYA and 10 mg/mL alpha-CD. We found that 0.025% CYA (alpha-CD[40 mg/mL]) resulted in the least corneal toxicity and penetrated in the cornea 5 to 10 times more than did lipophilic vehicle with CYA.

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Year:  1989        PMID: 2705275

Source DB:  PubMed          Journal:  Transplant Proc        ISSN: 0041-1345            Impact factor:   1.066


  5 in total

Review 1.  New agents for treating dry eye syndrome.

Authors:  Simon E Skalicky; Con Petsoglou; Avinash Gurbaxani; Clare L Fraser; Peter McCluskey
Journal:  Curr Allergy Asthma Rep       Date:  2013-06       Impact factor: 4.806

Review 2.  Ocular pharmacokinetics and safety of ciclosporin, a novel topical treatment for dry eye.

Authors:  Diane D-S Tang-Liu; Andrew Acheampong
Journal:  Clin Pharmacokinet       Date:  2005       Impact factor: 5.577

Review 3.  An overview on dry eye treatment: approaches for cyclosporin a delivery.

Authors:  Burçin Yavuz; Sibel Bozdağ Pehlivan; Nurşen Unlü
Journal:  ScientificWorldJournal       Date:  2012-04-24

4.  Preparation and Characterisation of a Cyclodextrin-Complexed Mānuka Honey Microemulsion for Eyelid Application.

Authors:  Ilva D Rupenthal; Priyanka Agarwal; Benedict Uy; Jaeun Kim; Angela A Cunningham; Ali Seyfoddin; Simon Swift; Jennifer P Craig
Journal:  Pharmaceutics       Date:  2022-07-19       Impact factor: 6.525

5.  A phase II study of Mirvetuximab Soravtansine in triple-negative breast cancer.

Authors:  Clinton Yam; Gaiane M Rauch; Tanbin Rahman; Meghan Karuturi; Elizabeth Ravenberg; Jason White; Alyson Clayborn; Pamela McCarthy; Sausan Abouharb; Bora Lim; Jennifer K Litton; David L Ramirez; Sadia Saleem; James Stec; W Fraser Symmans; Lei Huo; Senthil Damodaran; Ryan Sun; Stacy L Moulder
Journal:  Invest New Drugs       Date:  2020-09-28       Impact factor: 3.850

  5 in total

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