Keitaro Sofue1,2, Xiaodong Zhong3, Marcel D Nickel4, Brian M Dale5, Mustafa R Bashir6,7. 1. Department of Radiology, Duke University Medical Center, Box 3808, Durham, NC, 27710, USA. 2. Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Japan. 3. Siemens Healthcare, Atlanta, GA, USA. 4. Siemens Healthcare, Erlangen, Germany. 5. Siemens Healthcare, Morrisville, NC, USA. 6. Department of Radiology, Duke University Medical Center, Box 3808, Durham, NC, 27710, USA. mustafa.bashir@duke.edu. 7. Center for Advanced Magnetic Resonance Development, Duke University Medical Center, Durham, NC, USA. mustafa.bashir@duke.edu.
Abstract
OBJECTIVE: To assess changes in liver proton density fat fraction (PDFF) and R 2* measurements in the presence of changes in tissue relaxation rates induced by administrating gadoxetic acid, using two different image reconstruction methods at 3T MRI. METHODS: Forty-five patients were imaged at 3T with chemical-shift-based MRI sequences before and 20 min after administration of gadoxetic acid. Image reconstructions were performed using hybrid and complex methods to obtain PDFF and R 2* images. A single radiologist measured PDFF and R 2* values on precontrast and postcontrast images. Precontrast and postcontrast PDFF values were compared using intraclass correlation coefficient (ICC), linear regression, and Bland-Altman analysis. Changes in R 2* values from precontrast to postcontrast were correlated with relative liver enhancement (RLE) based on signal intensities on T 1-weighted images using Spearman's rank correlation. RESULTS: PDFF values were similar between precontrast and postcontrast images (ICC = 0.99, linear regression slopes = 0.98, mean difference = -0.21 to -0.31%). PDFF measurements were stable between precontrast and postcontrast images. Changes in R 2* values were correlated with RLE (p < 0.001, r = 0.49-0.71). CONCLUSIONS: PDFF measurements from both image reconstruction methods are stable in the presence of changes in tissue relaxation rates after administering gadoxetic acid at 3T MRI. Changes in R 2* values correlate with established measures of gadoxetic acid uptake based on T 1-weighted images.
OBJECTIVE: To assess changes in liver proton density fat fraction (PDFF) and R 2* measurements in the presence of changes in tissue relaxation rates induced by administrating gadoxetic acid, using two different image reconstruction methods at 3T MRI. METHODS: Forty-five patients were imaged at 3T with chemical-shift-based MRI sequences before and 20 min after administration of gadoxetic acid. Image reconstructions were performed using hybrid and complex methods to obtain PDFF and R 2* images. A single radiologist measured PDFF and R 2* values on precontrast and postcontrast images. Precontrast and postcontrast PDFF values were compared using intraclass correlation coefficient (ICC), linear regression, and Bland-Altman analysis. Changes in R 2* values from precontrast to postcontrast were correlated with relative liver enhancement (RLE) based on signal intensities on T 1-weighted images using Spearman's rank correlation. RESULTS: PDFF values were similar between precontrast and postcontrast images (ICC = 0.99, linear regression slopes = 0.98, mean difference = -0.21 to -0.31%). PDFF measurements were stable between precontrast and postcontrast images. Changes in R 2* values were correlated with RLE (p < 0.001, r = 0.49-0.71). CONCLUSIONS: PDFF measurements from both image reconstruction methods are stable in the presence of changes in tissue relaxation rates after administering gadoxetic acid at 3T MRI. Changes in R 2* values correlate with established measures of gadoxetic acid uptake based on T 1-weighted images.
Authors: Houchun H Hu; Takeshi Yokoo; Mustafa R Bashir; Claude B Sirlin; Diego Hernando; Dariya Malyarenko; Thomas L Chenevert; Mark A Smith; Suraj D Serai; Michael S Middleton; Walter C Henderson; Gavin Hamilton; Jean Shaffer; Yunhong Shu; Jean A Tkach; Andrew T Trout; Nancy Obuchowski; Jean H Brittain; Edward F Jackson; Scott B Reeder Journal: Radiology Date: 2021-01-19 Impact factor: 11.105