Dorien H Nieman1, Sara Dragt2, Esther D A van Duin3, Nadine Denneman2, Jozefien M Overbeek2, Lieuwe de Haan2, Judith Rietdijk4, Helga K Ising5, Rianne M C Klaassen6, Thérèse van Amelsvoort3, Lex Wunderink7, Mark van der Gaag8, Don H Linszen9. 1. Department of Psychiatry, Academic Medical Center, Amsterdam, the Netherlands. Electronic address: d.h.nieman@amc.nl. 2. Department of Psychiatry, Academic Medical Center, Amsterdam, the Netherlands. 3. Department of Psychiatry and Psychology, Maastricht University, the Netherlands. 4. Department of Early Psychosis, Dijk en Duin Psychiatric Institute, Castricum, The Netherlands. 5. Department of Psychiatry, Parnassia Psychiatric Institute, The Hague, the Netherlands. 6. Bascule, Child and Adolescent Psychiatry, Amsterdam, the Netherlands. 7. Friesland Mental Health Service, Department of Education and Research, the Netherlands. 8. Department of Psychiatry, Parnassia Psychiatric Institute, The Hague, the Netherlands; VU University and EMGO(+) Institute for Mental health and Care Research, Amsterdam, the Netherlands. 9. Department of Psychiatry, Academic Medical Center, Amsterdam, the Netherlands; Department of Psychiatry and Psychology, Maastricht University, the Netherlands.
Abstract
BACKGROUND: Epidemiological and retrospective studies suggest a cannabis x catechol-O-methyltransferase (COMT) Val(158)Met interaction effect on development of psychosis. The aim of this study was to examine this interaction and its association with severity of subclinical symptoms in people with an At Risk Mental State (ARMS) for psychosis. METHODS: Severity of symptoms, cannabis use and genotype were assessed at baseline in 147 help-seeking young adults who met the ARMS criteria and agreed to participate in the Dutch Early Detection and Intervention (EDIE-NL) trial. RESULTS: Cannabis use and COMT Val-allele showed an interaction effect in ARMS subjects. Subjects who were weekly cannabis users at some point prior to entering the study showed more severe positive symptoms. This effect increased if they were carriers of the COMT Val-allele and even more so if they were homozygous for the Val-allele. CONCLUSIONS: Our results suggest that the COMT Val(158)Met polymorphism moderates the effect of regular cannabis use on severity of subclinical psychotic symptoms.
BACKGROUND: Epidemiological and retrospective studies suggest a cannabis x catechol-O-methyltransferase (COMT) Val(158)Met interaction effect on development of psychosis. The aim of this study was to examine this interaction and its association with severity of subclinical symptoms in people with an At Risk Mental State (ARMS) for psychosis. METHODS: Severity of symptoms, cannabis use and genotype were assessed at baseline in 147 help-seeking young adults who met the ARMS criteria and agreed to participate in the Dutch Early Detection and Intervention (EDIE-NL) trial. RESULTS: Cannabis use and COMT Val-allele showed an interaction effect in ARMS subjects. Subjects who were weekly cannabis users at some point prior to entering the study showed more severe positive symptoms. This effect increased if they were carriers of the COMT Val-allele and even more so if they were homozygous for the Val-allele. CONCLUSIONS: Our results suggest that the COMTVal(158)Met polymorphism moderates the effect of regular cannabis use on severity of subclinical psychotic symptoms.
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