Carlo Agostoni1, Alberto Edefonti, Edoardo Calderini, Emilio Fossali, Carla Colombo, Alberto Battezzati, Simona Bertoli, Gregorio Milani, Arianna Bisogno, Michela Perrone, Silvia Bettocchi, Valentina De Cosmi, Alessandra Mazzocchi, Giorgio Bedogni. 1. *Pediatric Medium Intensity Care Unit, Department of Clinical Science and Community Health, Università degli Studi di Milano, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico †Pediatric Nephrology and Dialysis Unit ‡Pediatric Intensive Care Unit §Pediatric Emergency Unit ||Cystic Fibrosis Center, Fondazione IRCCS Cà Granda-Ospedale Maggiore Policlinico, University of Milan ¶International Center for the Assessment of Nutritional Status, University of Milan #Laboratorio di Statistica Medica, Biometria ed Epidemiologia 'G.A. Maccacaro' Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Abstract
BACKGROUND AND AIM: The resting energy expenditure (REE) of ill children is commonly estimated from prediction formulae developed in healthy children. The aim of the present study was to evaluate the accuracy of commonly employed REE prediction formulae versus indirect calorimetry in hospitalized children. METHODS: We performed a cross-sectional study of 236 infants, children, and adolescents consecutively admitted to the Intermediate Care, Nephrology, Intensive Care, Emergency, and Cystic Fibrosis Units of the De Marchi Pediatric Hospital (Milan, Italy) between September 2013 and March 2015. REE was measured by indirect calorimetry and estimated using the World Health Organization (WHO), Harris-Benedict, Schofield, and Oxford formulae. RESULTS: The mean (standard deviation) difference between the estimated and measured REE was: -1 (234) kcal/day for the WHO formula; 82 (286) kcal/day for the Harris-Benedict formula; 2 (215) kcal/day for the Schofield-weight formula; -2 (214) kcal/day for the Schofield-weight and height formula; and -5 (221) kcal/day for the Oxford formula. Even though the WHO, Schofield, and Oxford formulae gave accurate estimates of REE at the population level (small mean bias), all the formulae were not accurate enough to be employed at the individual level (large SD of bias). CONCLUSIONS: The WHO, Harris-Benedict, Schofield, and Oxford formulae should not be used to estimate REE in hospitalized children.
BACKGROUND AND AIM: The resting energy expenditure (REE) of ill children is commonly estimated from prediction formulae developed in healthy children. The aim of the present study was to evaluate the accuracy of commonly employed REE prediction formulae versus indirect calorimetry in hospitalized children. METHODS: We performed a cross-sectional study of 236 infants, children, and adolescents consecutively admitted to the Intermediate Care, Nephrology, Intensive Care, Emergency, and Cystic Fibrosis Units of the De Marchi Pediatric Hospital (Milan, Italy) between September 2013 and March 2015. REE was measured by indirect calorimetry and estimated using the World Health Organization (WHO), Harris-Benedict, Schofield, and Oxford formulae. RESULTS: The mean (standard deviation) difference between the estimated and measured REE was: -1 (234) kcal/day for the WHO formula; 82 (286) kcal/day for the Harris-Benedict formula; 2 (215) kcal/day for the Schofield-weight formula; -2 (214) kcal/day for the Schofield-weight and height formula; and -5 (221) kcal/day for the Oxford formula. Even though the WHO, Schofield, and Oxford formulae gave accurate estimates of REE at the population level (small mean bias), all the formulae were not accurate enough to be employed at the individual level (large SD of bias). CONCLUSIONS: The WHO, Harris-Benedict, Schofield, and Oxford formulae should not be used to estimate REE in hospitalized children.
Authors: Gregorio P Milani; Marco Silano; Alessandra Mazzocchi; Silvia Bettocchi; Valentina De Cosmi; Carlo Agostoni Journal: Pediatr Res Date: 2020-11-23 Impact factor: 3.756
Authors: Giorgio Bedogni; Simona Bertoli; Ramona De Amicis; Andrea Foppiani; Alessandra De Col; Gabriella Tringali; Nicoletta Marazzi; Valentina De Cosmi; Carlo Agostoni; Alberto Battezzati; Alessandro Sartorio Journal: Nutrients Date: 2020-05-14 Impact factor: 5.717
Authors: Osman Serhat Tokgoz; Figen Guney; Ahmet Kaya; Ahmet Bugrul; Esra Eruyar; Huseyin Buyukgol; Abdullah Seyithanoglu; Mehmet Sinan Iyisoy Journal: Sisli Etfal Hastan Tip Bul Date: 2021-12-29
Authors: Valentina De Cosmi; Alessandra Mazzocchi; Gregorio Paolo Milani; Edoardo Calderini; Silvia Scaglioni; Silvia Bettocchi; Veronica D'Oria; Thomas Langer; Giulia C I Spolidoro; Ludovica Leone; Alberto Battezzati; Simona Bertoli; Alessandro Leone; Ramona Silvana De Amicis; Andrea Foppiani; Carlo Agostoni; Enzo Grossi Journal: J Clin Med Date: 2020-04-05 Impact factor: 4.241