INTRODUCTION: Anemia, inflammation and hypoalbuminemia are frequent disorders among patients underwent hemodialysis. There are few national data, particularly from Northeast region where anemia and malnourished were common findings, analyzing the association between these conditions and clinical outcomes. OBJECTIVE: The aim of this study was to evaluate the impact of the presence of anemia, inflammation and hypoalbuminemia on clinical outcomes (death and hospitalization) of hemodialysis patients. METHODS: In this prospective observational study 221 adult patients were evaluated, considering the presence of anemia (hemoglobin ≤ 10 g/dL), inflammation (C-reactive protein (CRP) ≥ 0,5 mg/dL) and hypoalbuminemia (albumin < 3,8 g/ dL) at baseline. Clinical outcomes were recorded over 13 months. RESULTS: The occurrence of hospitalization and death did not differ between the groups with and without anemia or inflammation. Patients with hypoalbuminemia had more hospitalizations, and the presence of hypoalbuminemia was associated with shorter hospitalization event-free time (p = 0.008). There was a trend of shorter hospitalization event-free time among patients with increased PCR (p = 0.08). There was no correlation between albumin and CRP levels. The presence of anemia, inflammation and hypoalbuminemia were not associated with lower survival. Adjusting for confounders, hypoalbuminemia was a predictor of hospitalization in hemodialyzed patients. CONCLUSION: The presence of hypoalbuminemia, but not anemia or inflammation, was able to predict hospitalization in hemodialysis patients.
INTRODUCTION:Anemia, inflammation and hypoalbuminemia are frequent disorders among patients underwent hemodialysis. There are few national data, particularly from Northeast region where anemia and malnourished were common findings, analyzing the association between these conditions and clinical outcomes. OBJECTIVE: The aim of this study was to evaluate the impact of the presence of anemia, inflammation and hypoalbuminemia on clinical outcomes (death and hospitalization) of hemodialysis patients. METHODS: In this prospective observational study 221 adult patients were evaluated, considering the presence of anemia (hemoglobin ≤ 10 g/dL), inflammation (C-reactive protein (CRP) ≥ 0,5 mg/dL) and hypoalbuminemia (albumin < 3,8 g/ dL) at baseline. Clinical outcomes were recorded over 13 months. RESULTS: The occurrence of hospitalization and death did not differ between the groups with and without anemia or inflammation. Patients with hypoalbuminemia had more hospitalizations, and the presence of hypoalbuminemia was associated with shorter hospitalization event-free time (p = 0.008). There was a trend of shorter hospitalization event-free time among patients with increased PCR (p = 0.08). There was no correlation between albumin and CRP levels. The presence of anemia, inflammation and hypoalbuminemia were not associated with lower survival. Adjusting for confounders, hypoalbuminemia was a predictor of hospitalization in hemodialyzed patients. CONCLUSION: The presence of hypoalbuminemia, but not anemia or inflammation, was able to predict hospitalization in hemodialysis patients.
Authors: Nicole Hryciw; Michael Joannidis; Swapnil Hiremath; Jeannie Callum; Edward G Clark Journal: Clin J Am Soc Nephrol Date: 2020-10-28 Impact factor: 8.237
Authors: E J F Santos; E V Hortegal; H O Serra; J S Lages; N Salgado-Filho; A M Dos Santos Journal: Braz J Med Biol Res Date: 2018-05-07 Impact factor: 2.590