Literature DB >> 27049333

The Natural Product Essramycin and Three of Its Isomers Are Devoid of Antibacterial Activity.

Huan Wang1, Dusan Hesek1, Mijoon Lee1, Elena Lastochkin1, Allen G Oliver1, Mayland Chang1, Shahriar Mobashery1.   

Abstract

Four possible isomers of essramycin, a natural product from a marine Streptomyces species isolated from the Egyptian Mediterranean coast, were synthesized. The structures for the isomers were assigned unequivocally by (1)H NMR, (13)C NMR, high-resolution mass spectrometry, and X-ray crystal structure determinations. Notwithstanding the earlier report of broad-spectrum antibacterial activity for the natural product, none of the four isomers exhibited any such activity.

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Year:  2016        PMID： 27049333      PMCID： PMC5436578          DOI： 10.1021/acs.jnatprod.6b00057

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  7 in total

Review 1.  How many antibiotics are produced by the genus Streptomyces?

Authors:  M G Watve; R Tickoo; M M Jog; B D Bhole
Journal:  Arch Microbiol       Date:  2001-11       Impact factor: 2.552

2.  Synthesis of essramycin and comparison of its antibacterial activity.

Authors:  Ernest H L Tee; Tomislav Karoli; Soumya Ramu; Johnny X Huang; Mark S Butler; Matthew A Cooper
Journal:  J Nat Prod       Date:  2010-11-04       Impact factor: 4.050

3.  Synthesis and evaluation of 1,2,4-triazolo[1,5-a]pyrimidines as antibacterial agents against Enterococcus faecium.

Authors:  Huan Wang; Mijoon Lee; Zhihong Peng; Blas Blázquez; Elena Lastochkin; Malika Kumarasiri; Renee Bouley; Mayland Chang; Shahriar Mobashery
Journal:  J Med Chem       Date:  2015-05-12       Impact factor: 7.446

4.  A short synthesis of the triazolopyrimidine antibiotic essramycin.

Authors:  Ugo Battaglia; Christopher J Moody
Journal:  J Nat Prod       Date:  2010-09-13       Impact factor: 4.050

Review 5.  Molecular regulation of antibiotic biosynthesis in streptomyces.

Authors:  Gang Liu; Keith F Chater; Govind Chandra; Guoqing Niu; Huarong Tan
Journal:  Microbiol Mol Biol Rev       Date:  2013-03       Impact factor: 11.056

6.  Essramycin: a first triazolopyrimidine antibiotic isolated from nature.

Authors:  Mervat M A El-Gendy; Mohamed Shaaban; Khaled A Shaaban; Ahmed M El-Bondkly; Hartmut Laatsch
Journal:  J Antibiot (Tokyo)       Date:  2008-03       Impact factor: 2.649

7.  Discovery of a new class of non-β-lactam inhibitors of penicillin-binding proteins with Gram-positive antibacterial activity.

Authors:  Peter I O'Daniel; Zhihong Peng; Hualiang Pi; Sebastian A Testero; Derong Ding; Edward Spink; Erika Leemans; Marc A Boudreau; Takao Yamaguchi; Valerie A Schroeder; William R Wolter; Leticia I Llarrull; Wei Song; Elena Lastochkin; Malika Kumarasiri; Nuno T Antunes; Mana Espahbodi; Katerina Lichtenwalter; Mark A Suckow; Sergei Vakulenko; Shahriar Mobashery; Mayland Chang
Journal:  J Am Chem Soc       Date:  2014-02-21       Impact factor: 15.419
  7 in total
  2 in total

1.  Unconventional Antibacterials and Adjuvants.

Authors:  Mayland Chang; Kiran V Mahasenan; Juan A Hermoso; Shahriar Mobashery
Journal:  Acc Chem Res       Date:  2021-01-29       Impact factor: 22.384

Review 2.  1,2,4-Triazolo[1,5-a]pyrimidines in drug design.

Authors:  Killian Oukoloff; Bobby Lucero; Karol R Francisco; Kurt R Brunden; Carlo Ballatore
Journal:  Eur J Med Chem       Date:  2019-01-14       Impact factor: 6.514
  2 in total

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