| Literature DB >> 27049258 |
Abstract
Leukemia is a group of malignant clone diseases of hematopoietic stem cells, while drug resistance (DR) has become the primary cause of chemotherapy failure. p38 mitogen-activated protein kinase (p38MAPK) signaling pathway induces cell activation, proliferation and apoptosis in response to extracellular stimuli. Recent studies have shown that p38 MAPK signaling pathway is closely associated with DR in leukemia. The present article reviews the relationship between p38 MAPK signaling pathway and DR in leukemia.Entities:
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Year: 2016 PMID： 27049258
Source DB: PubMed Journal: Eur Rev Med Pharmacol Sci ISSN： 1128-3602 Impact factor: 3.507