| Literature DB >> 27049042 |
Cai-Mei Zheng1, Jin-Quan Zheng2, Chia-Chao Wu3, Chien-Lin Lu4, Jia-Fwu Shyu5, Hsu Yung-Ho1, Mei-Yi Wu6, I-Jen Chiu7, Yuan-Hung Wang8, Yuh-Feng Lin1, Kuo-Cheng Lu9.
Abstract
Chronic kidney disease (CKD) patients experience bone loss and fracture because of a specific CKD-related systemic disorder known as CKD-mineral bone disorder (CKD-MBD). The bone turnover, mineralization, and volume (TMV) system describes the morphological bone lesions in renal osteodystrophy related to CKD-MBD. Bone turnover and bone volume are defined as high, normal, or low, and bone mineralization is classified as normal or abnormal. All types of bone histology related to TMV are responsible for both bone quantity and bone quality losses in CKD patients. This review focuses on current bone quantity and bone quality losses in CKD patients and finally discusses potential therapeutic measures.Entities:
Keywords: Bone quantity and bone quality losses; Bone remodeling; Chronic kidney disease–mineral bone disorder (CKD–MBD); Vitamin D therapy
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Year: 2016 PMID： 27049042 DOI： 10.1016/j.bone.2016.03.017
Source DB: PubMed Journal: Bone ISSN： 1873-2763 Impact factor: 4.398