Yi-Dan Chen1,2, Xiao-Qing Jin3, Mai-Hong Yu1, Ying Fang2, Li-Qin Huang4. 1. Department of Acupuncture, Zhejiang Hospital, Hangzhou, 310013, China. 2. Department of Neurobiology and Acupuncture Research, the Third College of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, 310053, China. 3. Department of Acupuncture, Zhejiang Hospital, Hangzhou, 310013, China. zjyyjxq@163.com. 4. Department of Otolaryngology, Hospital of Traditional Chinese Medicine of Hangzhou City, Hangzhou, 310007, China.
Abstract
OBJECTIVE: To evaluate the effect and safety of acupuncture therapy on patients with moderate to severe allergic rhinitis. METHODS: A non-randomized controlled design was used to compare between the acupuncture group and the medication group. The acupuncture group received 8-week acupuncture therapy, and the medication group received budesonide nasal spray with cetirizine tablets for 8 weeks. The clinical symptoms and signs were analyzed before treatment, at 4 and 8 weeks after the start of treatment, and at 12 weeks after the end of treatment. Furthermore, the clinical efficacy and safety indicators were compared between the two groups. RESULTS: A total of 76 participants consisting of 38 in each of the two groups were enrolled. The scores of each clinical symptom and sign, including sneezing, runny nose, stuffy nose, nasal itching, and turbinate edema, and the total scores decreased over time in both groups (all P<0.05); and no difference was found in the scores between the two groups (P>0.05). There was no statistically significant difference in the effective rates of the acupuncture group at 4 and 8 weeks after the start of treatment as well as at 12-week follow-up compared with those of the medication group (83.3% vs. 91.2%, and 94.4 % vs. 85.3%; and 80.6 % vs. 82.4%, all P>0.05). Experimental items including blood routine, urine routine, aspartate transaminase, alanine aminotransferase, urea nitrogen and creatinine were all in the normal reference ranges during the treatment in the acupuncture group. CONCLUSIONS:Acupuncture therapy has a comparable effect to the medication treatment on patients with moderate to severe allergic rhinitis, and it is safe with no severe adverse effects.
RCT Entities:
OBJECTIVE: To evaluate the effect and safety of acupuncture therapy on patients with moderate to severe allergic rhinitis. METHODS: A non-randomized controlled design was used to compare between the acupuncture group and the medication group. The acupuncture group received 8-week acupuncture therapy, and the medication group received budesonide nasal spray with cetirizine tablets for 8 weeks. The clinical symptoms and signs were analyzed before treatment, at 4 and 8 weeks after the start of treatment, and at 12 weeks after the end of treatment. Furthermore, the clinical efficacy and safety indicators were compared between the two groups. RESULTS: A total of 76 participants consisting of 38 in each of the two groups were enrolled. The scores of each clinical symptom and sign, including sneezing, runny nose, stuffy nose, nasal itching, and turbinate edema, and the total scores decreased over time in both groups (all P<0.05); and no difference was found in the scores between the two groups (P>0.05). There was no statistically significant difference in the effective rates of the acupuncture group at 4 and 8 weeks after the start of treatment as well as at 12-week follow-up compared with those of the medication group (83.3% vs. 91.2%, and 94.4 % vs. 85.3%; and 80.6 % vs. 82.4%, all P>0.05). Experimental items including blood routine, urine routine, aspartate transaminase, alanine aminotransferase, ureanitrogen and creatinine were all in the normal reference ranges during the treatment in the acupuncture group. CONCLUSIONS: Acupuncture therapy has a comparable effect to the medication treatment on patients with moderate to severe allergic rhinitis, and it is safe with no severe adverse effects.
Authors: De-Min Han; Luo Zhang; Dan Huang; Yang-Feng Wu; Zhen Dong; Geng Xu; Wei-Jia Kong; Ji-Min Bao; Bing Zhou; Shen-Qing Wang; De-Hui Wang; Qiu-Ping Wang Journal: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi Date: 2007-05
Authors: Myeong Soo Lee; Max H Pittler; Byung-Cheul Shin; Jong-In Kim; Edzard Ernst Journal: Ann Allergy Asthma Immunol Date: 2009-04 Impact factor: 6.347
Authors: Jan L Brozek; Jean Bousquet; Carlos E Baena-Cagnani; Sergio Bonini; G Walter Canonica; Thomas B Casale; Roy Gerth van Wijk; Ken Ohta; Torsten Zuberbier; Holger J Schünemann Journal: J Allergy Clin Immunol Date: 2010-09 Impact factor: 10.793
Authors: S M Choi; J-E Park; S-S Li; H Jung; M Zi; T-H Kim; S Jung; A Kim; M Shin; J-U Sul; Z Hong; Z Jiping; S Lee; H Liyun; K Kang; L Baoyan Journal: Allergy Date: 2012-12-18 Impact factor: 13.146
Authors: Benno Brinkhaus; Miriam Ortiz; Claudia M Witt; Stephanie Roll; Klaus Linde; Florian Pfab; Bodo Niggemann; Josef Hummelsberger; András Treszl; Johannes Ring; Torsten Zuberbier; Karl Wegscheider; Stefan N Willich Journal: Ann Intern Med Date: 2013-02-19 Impact factor: 25.391
Authors: Bradley F Marple; John A Fornadley; Alpen A Patel; Stanley M Fineman; Leonard Fromer; John H Krouse; Bobby Q Lanier; Peter Penna Journal: Otolaryngol Head Neck Surg Date: 2007-06 Impact factor: 3.497
Authors: Charlie Changli Xue; Robert English; Jerry Jiansheng Zhang; Cliff Da Costa; Chun Guang Li Journal: Am J Chin Med Date: 2002 Impact factor: 4.667