Jia Shen1, Gregory LaChaud2, Swati Shrestha1, Greg Asatrian1, Xinli Zhang3, Sarah M Dry4, Chia Soo5, Kang Ting3, Aaron W James6. 1. Division of Growth and Development and Section of Orthodontics, School of Dentistry UCLA, Los Angeles, CA 90095, United States; Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, CA 90095, United States. 2. Division of Growth and Development and Section of Orthodontics, School of Dentistry UCLA, Los Angeles, CA 90095, United States; Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, CA 90095, United States; Vanderbilt University School of Medicine, Nashville, TN 37212, United States. 3. Division of Growth and Development and Section of Orthodontics, School of Dentistry UCLA, Los Angeles, CA 90095, United States. 4. Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, CA 90095, United States. 5. Division of Plastic and Reconstructive Surgery, Department of Surgery, UCLA, Los Angeles, CA 90095, United States; UCLA and Orthopaedic Hospital, Department of Orthopaedic Surgery and the Orthopaedic Hospital Research Center, Los Angeles, CA 90095, United States. 6. Division of Growth and Development and Section of Orthodontics, School of Dentistry UCLA, Los Angeles, CA 90095, United States; Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, CA 90095, United States; UCLA and Orthopaedic Hospital, Department of Orthopaedic Surgery and the Orthopaedic Hospital Research Center, Los Angeles, CA 90095, United States; David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, United States.
Abstract
BACKGROUND/AIMS: NELL-1 is a novel osteochondral differentiation factor protein with increasing usage in tissue engineering. Previously, we reported the expression patterns of NELL-1 in bone-forming skeletal tumors. With increasing interest in the use of NELL-1 protein, we sought to examine the expression of NELL-1 in cartilage-forming tumors. METHODS: Immunohistochemical expression was examined in human pathologic specimens. RESULTS: Consistent NELL-1 overexpression across all cartilage-forming tumors was observed. Similar degrees of expression were observed in enchondroma, chondrosarcoma, and chondroblastic osteosarcoma. NELL-1 expression did not significantly vary by tumor grade. CONCLUSION: In summary, NELL-1 demonstrates reliable and consistent expression across cartilage-forming skeletal tumors.
BACKGROUND/AIMS: NELL-1 is a novel osteochondral differentiation factor protein with increasing usage in tissue engineering. Previously, we reported the expression patterns of NELL-1 in bone-forming skeletal tumors. With increasing interest in the use of NELL-1 protein, we sought to examine the expression of NELL-1 in cartilage-forming tumors. METHODS: Immunohistochemical expression was examined in human pathologic specimens. RESULTS: Consistent NELL-1 overexpression across all cartilage-forming tumors was observed. Similar degrees of expression were observed in enchondroma, chondrosarcoma, and chondroblastic osteosarcoma. NELL-1 expression did not significantly vary by tumor grade. CONCLUSION: In summary, NELL-1 demonstrates reliable and consistent expression across cartilage-forming skeletal tumors.
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